Department of Medical Biochemistry, DR. A.L.M. P-G. I.B.M.S., University of Madras, Taramani Campus, Chennai - 600 113. India.
Asian Pac J Trop Med. 2012 Dec;5(12):956-61. doi: 10.1016/S1995-7645(12)60181-3.
To explore the protective effect of the drug Semecarpus anacardium (S. anacardium)on altered glucose metabolism in diabetic rats.
Type 2 diabetes mellitus was induced by feeding rats with high fat diet followed by single intraperitoneal injection of streptozotocin (STZ) (35 mg/kg b.w.). Seven days after STZ induction, diabetic rats received nut milk extract of S. anacardium Linn. nut milk extract orally at a dosage of 200 mg/kg daily for 4 weeks. The effect of nut milk extract of S. anacardium on blood glucose, plasma insulin, glucose metabolising enzymes and GSK were studied.
Treatment with SA extract showed a significant reduction in blood glucose levels and increase in plasma insulin levels and also increase in HOMA - β and decrease in HOMA -IR. The drug significantly increased the activity of glycolytic enzymes and glucose-6-phosphate dehydrogenase activity and increased the glycogen content in liver of diabetic rats while reducing the activities of gluconeogenic enzymes. The drug also effectively ameliorated the alterations in GSK-3 mRNA expression.
Overall, the present study demonstrates the possible mechanism of glucose regulation of S. anacardium suggestive of its therapeutic potential for the management of diabetes mellitus.
探索番荔枝（S. anacardium）药物对糖尿病大鼠糖代谢改变的保护作用。
采用高脂饲料喂养大鼠，随后单次腹腔注射链脲佐菌素（STZ）（35mg/kg b.w.）诱导 2 型糖尿病。STZ 诱导后 7 天，糖尿病大鼠每日口服番荔枝核奶提取物 200mg/kg，连续 4 周。研究番荔枝核奶提取物对血糖、血浆胰岛素、糖代谢酶和 GSK 的影响。
SA 提取物治疗可显著降低血糖水平，增加血浆胰岛素水平，同时增加 HOMA-β并降低 HOMA-IR。该药物还能显著增加糖酵解酶和葡萄糖-6-磷酸脱氢酶的活性，增加糖尿病大鼠肝脏的糖原含量，同时降低糖异生酶的活性。该药物还能有效改善 GSK-3mRNA 表达的改变。
综上所述，本研究表明番荔枝具有调节血糖的可能机制，提示其在糖尿病治疗方面具有潜在的治疗价值。
