自发活动对成年肥胖和瘦型 Zucker 大鼠每日能量消耗的贡献。

Contribution of spontaneous activity to daily energy expenditure of adult obese and lean Zucker rats.

作者信息

Keesey R E, Swiergiel A H, Corbett S W

机构信息

Department of Psychology, University of Wisconsin, Madison 53706.

出版信息

Physiol Behav. 1990 Aug;48(2):327-31. doi: 10.1016/0031-9384(90)90322-u.

DOI:10.1016/0031-9384(90)90322-u

PMID:2255740

Abstract

The contribution of somatomotor activity to daily energy expenditure was estimated in 10-month-old, weight-stable, obese (fa/fa) and lean (Fa/?) Zucker rats. Total and resting heat production were assessed by recording oxygen consumption and stabilimeter activity each minute for five consecutive days in free-feeding animals. The number of activity counts, as well as their circadian pattern of occurrence, were highly similar in lean and obese groups. Likewise, the percentage of daily energy expenditure committed by the obese rats to activity was nearly identical to that of leans (19.3 vs. 19.7%, respectively). Observing these rats for one additional day under postabsorptive conditions produced similar estimates of their daily expenditure on activity. Thus, unlike prior estimates based on wheel-running behavior, continuous measurement of stabilimeter behavior indicates that both the proportion of daily expenditure on activity by fa/fa rats and its temporal pattern of occurrence are notably normal. Accordingly, it is concluded that maintenance of obesity in weight-stable adult obese Zucker rats does not depend upon a reduced expenditure on activity.

摘要

在10月龄、体重稳定的肥胖（fa/fa）和瘦（Fa/?） Zucker大鼠中，评估了躯体运动活动对每日能量消耗的贡献。通过在自由进食的动物中连续五天每分钟记录氧气消耗量和安定计活动，来评估总产热和静息产热。肥胖组和瘦组的活动计数数量及其昼夜发生模式高度相似。同样，肥胖大鼠用于活动的每日能量消耗百分比与瘦大鼠几乎相同（分别为19.3%和19.7%）。在吸收后条件下再观察这些大鼠一天，得出了它们每日活动消耗的类似估计值。因此，与之前基于轮转行为的估计不同，对安定计行为的连续测量表明，fa/fa大鼠每日活动消耗的比例及其发生的时间模式都明显正常。因此，可以得出结论，体重稳定的成年肥胖Zucker大鼠的肥胖维持并不依赖于活动消耗的减少。