蒲桃种子内核的抗糖尿病活性
Anti - diabetic activity of the seed kernel of syzygium cumini linn.
作者信息
Nair R B, Santhakumari G
机构信息
C D R S Pharmacological Unit, Medical College, Trivandrum, Kerala - 695 011, India.
出版信息
Anc Sci Life. 1986 Oct;6(2):80-4.
Syzygium cumini seed kernel (aqueous suspension) was screened for its antibiadetic activity at the dose levels of 1g., 2g., 4g and 6 g/kg body weight. 4g / kg dose level was found to exhibit maximum hypoglycaemic effect (42.64%) in rabbits, 3hr. after medication. Like Tolbutamide the drug may also be promoting endogenous release of insulin. An extra pancreatic site of action of the drug cannot be ruled out, since it produced a significant decrease in the blood sugar level (17.04%) in alloxan diabetic rats.
对乌墨种子核（水悬浮液）在1克、2克、4克和6克/千克体重的剂量水平下进行了抗糖尿病活性筛选。发现在给药3小时后，4克/千克剂量水平在兔子身上表现出最大的降血糖作用（42.64%）。与甲苯磺丁脲一样，该药物也可能促进胰岛素的内源性释放。由于该药物在四氧嘧啶糖尿病大鼠中使血糖水平显著降低（17.04%），因此不能排除其胰腺外作用部位。
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