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2 型糖尿病易感基因与体重对胰岛自身免疫和 1 型糖尿病发生的相关性缺失。

Lack of association of type 2 diabetes susceptibility genotypes and body weight on the development of islet autoimmunity and type 1 diabetes.

机构信息

Institute of Diabetes Research, Helmholtz Zentrum München, Neuherberg, Germany.

出版信息

PLoS One. 2012;7(4):e35410. doi: 10.1371/journal.pone.0035410. Epub 2012 Apr 25.

DOI:10.1371/journal.pone.0035410
PMID:22558147
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3338842/
Abstract

AIM

To investigate whether type 2 diabetes susceptibility genes and body weight influence the development of islet autoantibodies and the rate of progression to type 1 diabetes.

METHODS

Genotyping for single nucleotide polymorphisms (SNP) of the type 2 diabetes susceptibility genes CDKAL1, CDKN2A/2B, FTO, HHEX-IDE, HMGA2, IGF2BP2, KCNJ11, KCNQ1, MTNR1B, PPARG, SLC30A8 and TCF7L2 was obtained in 1350 children from parents with type 1 diabetes participating in the BABYDIAB study. Children were prospectively followed from birth for islet autoantibodies and type 1 diabetes. Data on weight and height were obtained at 9 months, 2, 5, 8, 11, and 14 years of age.

RESULTS

None of type 2 diabetes risk alleles at the CDKAL1, CDKN2A/2B, FTO, HHEX-IDE, HMGA2, IGF2BP2, KCNJ11, KCNQ1, MTNR1B, PPARG and SLC30A8 loci were associated with the development of islet autoantibodies or diabetes. The type 2 diabetes susceptible genotype of TCF7L2 was associated with a lower risk of islet autoantibodies (7% vs. 12% by age of 10 years, P = 0.015, P(corrected) = 0.18). Overweight children at seroconversion did not progress to diabetes faster than non-overweight children (HR: 1.08; 95% CI: 0.48-2.45, P>0.05).

CONCLUSIONS

These findings do not support an association of type 2 diabetes risk factors with islet autoimmunity or acceleration of diabetes in children with a family history of type 1 diabetes.

摘要

目的

研究 2 型糖尿病易感基因和体重是否影响胰岛自身抗体的发展及向 1 型糖尿病的进展速度。

方法

在参与 BABYDIAB 研究的 1350 名父母患有 1 型糖尿病的儿童中，对 2 型糖尿病易感基因 CDKAL1、CDKN2A/2B、FTO、HHEX-IDE、HMGA2、IGF2BP2、KCNJ11、KCNQ1、MTNR1B、PPARG、SLC30A8 和 TCF7L2 的单核苷酸多态性（SNP）进行基因分型。从出生起对儿童进行前瞻性随访，以检测胰岛自身抗体和 1 型糖尿病。在 9 个月、2、5、8、11 和 14 岁时获取体重和身高数据。

结果

在 CDKAL1、CDKN2A/2B、FTO、HHEX-IDE、HMGA2、IGF2BP2、KCNJ11、KCNQ1、MTNR1B、PPARG 和 SLC30A8 基因座上，2 型糖尿病的风险等位基因均与胰岛自身抗体的发展或糖尿病无关。TCF7L2 的 2 型糖尿病易感基因型与胰岛自身抗体的风险较低相关（10 岁时的发生率分别为 7%和 12%，P = 0.015，P(corrected) = 0.18）。在发生自身抗体阳性转换的超重儿童中，进展为糖尿病的速度并不快于非超重儿童（HR：1.08；95%CI：0.48-2.45，P>0.05）。

结论

这些发现不支持 2 型糖尿病危险因素与胰岛自身免疫或有 1 型糖尿病家族史的儿童糖尿病进展加速之间存在关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d06b/3338842/be79303a98a9/pone.0035410.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d06b/3338842/83257b4eb4fe/pone.0035410.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d06b/3338842/76dcebe8a79b/pone.0035410.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d06b/3338842/be79303a98a9/pone.0035410.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d06b/3338842/83257b4eb4fe/pone.0035410.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d06b/3338842/76dcebe8a79b/pone.0035410.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d06b/3338842/be79303a98a9/pone.0035410.g003.jpg

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本文引用的文献

1
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Clin Chem. 2011 Dec;57(12):1693-702. doi: 10.1373/clinchem.2011.170662. Epub 2011 Oct 6.
2
Diabetes Antibody Standardization Program: evaluation of assays for insulin autoantibodies.糖尿病抗体标准化计划：胰岛素自身抗体检测方法的评估。
Diabetologia. 2010 Dec;53(12):2611-20. doi: 10.1007/s00125-010-1915-5. Epub 2010 Sep 25.
3
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
一项基于人群的队列研究表明，2型糖尿病患者患多发性硬化症的风险增加。
J Epidemiol. 2017 May;27(5):235-241. doi: 10.1016/j.je.2016.06.006. Epub 2017 Jan 27.
4
Islet biology, the CDKN2A/B locus and type 2 diabetes risk.胰岛生物学、CDKN2A/B基因座与2型糖尿病风险。
Diabetologia. 2016 Aug;59(8):1579-93. doi: 10.1007/s00125-016-3967-7. Epub 2016 May 7.
5
KCNJ11: Genetic Polymorphisms and Risk of Diabetes Mellitus.KCNJ11：基因多态性与糖尿病风险
J Diabetes Res. 2015;2015:908152. doi: 10.1155/2015/908152. Epub 2015 Sep 13.
6
Polymorphism of the FTO Gene Influences Body Weight in Children with Type 1 Diabetes without Severe Obesity.FTO 基因多态性对 1 型糖尿病非重度肥胖患儿体重的影响。
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7
Genetic insights into cardiometabolic risk factors.对心血管代谢危险因素的遗传学见解。
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5
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6
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Diabetologia. 2009 Oct;52(10):2072-8. doi: 10.1007/s00125-009-1461-1. Epub 2009 Jul 30.
7
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8
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9
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10
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