Department of Pediatrics, Endocrinology, Diabetology with Cardiology Division, Medical University of Bialystok, Bialystok 15-274, Poland.
Department of Paediatrics, Oncology, Haematology and Diabetology, Medical University of Lodz, Lodz 91-738, Poland.
Int J Endocrinol. 2014;2014:630712. doi: 10.1155/2014/630712. Epub 2014 Aug 19.
The objective was to compare the impact of clinical and genetic factors on body mass index (BMI) in children with type 1 diabetes (T1DM) without severe obesity. A total of 1,119 children with T1DM (aged 4-18 years) were qualified to take part in the study. All children were genotyped for variants of FTO, MC4R, INSIG2, FASN, NPC1, PTER, SIRT1, MAF, IRT1, and CD36. Results. Variants of FTO showed significant association with BMI-SDS in the T1DM group. The main factors influencing BMI-SDS in children with T1DM included female gender (P = 0.0003), poor metabolic control (P = 0.0001), and carriage of the A allele of the FTO rs9939609 gene (P = 0.02). Conclusion. Our research indicates, when assessing, the risk of overweight and obesity carriage of the A allele in the rs9939609 site of the FTO gene adds to that of female gender and poor metabolic control. This trial is registered with ClinicalTrials.gov (NCT01279161).
目的在于比较临床和遗传因素对 1 型糖尿病（T1DM）无严重肥胖儿童体重指数（BMI）的影响。共有 1119 名 T1DM 患儿（年龄 4-18 岁）符合参加研究的条件。所有患儿均进行 FTO、MC4R、INSIG2、FASN、NPC1、PTER、SIRT1、MAF、IRT1 和 CD36 变异体的基因分型。结果。FTO 的变异体与 T1DM 组的 BMI-SDS 有显著关联。影响 T1DM 儿童 BMI-SDS 的主要因素包括女性（P=0.0003）、代谢控制不佳（P=0.0001）和 FTO rs9939609 基因 A 等位基因的携带（P=0.02）。结论。我们的研究表明，在评估超重和肥胖风险时，FTO 基因 rs9939609 位点 A 等位基因的携带增加了女性和代谢控制不佳的风险。本试验已在 ClinicalTrials.gov（NCT01279161）注册。
