Safran A B
Clinique d'ophtalmologie, Hôpital cantonal universitaire de Genève.
Schweiz Rundsch Med Prax. 1990 Nov 27;79(48):1512-4.
Benign essential blepharospasm is a focal dystonia consisting in involuntary closure of the eyelids. Until early 80's, therapeutic modalities included only psychotropic drugs, biofeedback and surgery, which showed limited efficiency. Recently, it has been suggested to inject botulinum toxin in affected palpebral orbicularis muscles. Used in several thousands of patients, it has been found that this procedure provides significant temporary relief from spasms of the eyelids. Local side effects are minimal, and no systemic side effects have been demonstrated in patients with blepharospasm treated with botulinum toxin.
良性原发性睑痉挛是一种局限性肌张力障碍，表现为眼睑的不自主闭合。直到80年代初，治疗方法仅包括精神药物、生物反馈和手术，但效果有限。最近，有人建议在受影响的睑轮匝肌中注射肉毒杆菌毒素。在数千名患者中使用后发现，该方法能显著暂时缓解眼睑痉挛。局部副作用极小，在用肉毒杆菌毒素治疗的睑痉挛患者中未发现全身性副作用。
