Department of Radiation Oncology, Hallym University College of Medicine, Seoul, South Korea.
Med Phys. 2012 May;39(5):2524-35. doi: 10.1118/1.3700731.
The authors aim was to investigate the effects of using transmission and reflection scanning modes, the film orientation during scanning, and ambient room light on a dosimetry system based on the Gafchromic(TM) EBT2 film model.
For calibration, the films were cut to 3 × 3 cm(2) and irradiated from 20 to 700 cGy at the depth of maximum dose using 6 and 10 MV photon beams in a 10 × 10 cm(2) field size. Absolute dose calibration of the linear accelerator was done according to the TRS398 protocol. An FG65-G ionization chamber was used to monitor the dose while irradiating the films in solid water. The film pieces were scanned with an EPSON Expression 1680 Pro flatbed scanner in transmission and reflection modes. Authors investigated the effect of orientation on films and examined the optical properties of EBT2 film using an ellipsometer and an ultraviolet (UV)/visible spectrometer to explain the dosimetric dependence of the film on orientation during the scanning process. To investigate the effect of ambient room light, films were preirradiated in 6 and 10 MV photon beams with intensity-modulated radiotherapy (IMRT) quality assurance (QA) plans, and then exposed to room light, either directly for 2 days in a workroom or for 2 months in a film box. Gamma index pass criteria of (3%, 3 mm) were used.
The dose response curves based on net optical density (NOD) indicated that the reflection scanning mode can provide a better dose sensitivity than the transmission scanning mode, whereas the standard deviation of the dose is greater in reflection mode than in transmission mode. When the film was rotated 90° from the portrait orientation, the average dose of the EBT2 film decreased by 11.5-19.6% in transmission mode and by 1.5-2.3% in reflection mode. Using an ellipsometer, variation of the refractive index of EBT2 film-the birefringence property-was found to be the largest between 45° (1.72 and 1.71) and 135° (1.8 and 1.77) for 300 and 800 cGy. Absorption spectra of EBT2 films measured with spectrometer were the function of film orientation. The readings in reflection scanning mode were more stable against room light than those in transmission scanning mode, although dose readings increased in both modes after the films were exposed to room light.
The transmission scanning mode exhibited a strong dependence on film orientation during scanning and a change in optical density resulting from room light exposure, so a constant scanning orientation and minimal exposure to light can reduce uncertainty in the measured dose (23 ± 3%). The angular dependence was analyzed using Jones matrices and optical properties of EBT2 film were obtained using an ellipsometer and an UV/visible spectrometer. The reflection scanning mode has relatively good stability with respect to room light and film orientation on a scanner, although the large standard deviation of dose is a disadvantage in measurements of absolute dose. Reflection scanning mode can offer a potential advantage for film dosimetry in radiotherapy, although transmission scanning mode is still recommended for dosimetry as it provides better uncertainty results.
作者旨在研究在基于 Gafchromic(TM)EBT2 胶片模型的剂量测量系统中,使用透射和反射扫描模式、胶片在扫描过程中的方向以及环境室内光对剂量测量的影响。
为了进行校准,将胶片切成 3×3cm(2)大小,并在最大剂量深度处使用 6 和 10MV 光子束在 10×10cm(2)射野大小下从 20 到 700cGy 进行照射。根据 TRS398 协议对直线加速器进行绝对剂量校准。使用 FG65-G 电离室在固体水中照射胶片时监测剂量。作者使用 EPSON Expression 1680 Pro 平板扫描仪在透射和反射模式下扫描胶片。作者研究了胶片方向对胶片的影响,并使用椭圆偏振仪和紫外/可见分光光度计检查 EBT2 胶片的光学特性,以解释在扫描过程中胶片对方向的剂量依赖性。为了研究环境室内光的影响,将胶片在 6 和 10MV 光子束下用调强放疗(IMRT)质量保证(QA)计划预先照射,然后暴露于室内光下,要么直接在工作室中暴露 2 天,要么在胶片盒中暴露 2 个月。使用(3%,3mm)伽马指数通过率标准进行评估。
基于净光学密度(NOD)的剂量响应曲线表明,反射扫描模式可以提供比透射扫描模式更好的剂量灵敏度,而在反射模式下的剂量标准偏差大于透射模式。当胶片从纵向旋转 90°时,EBT2 胶片的平均剂量在透射模式下降低了 11.5-19.6%,在反射模式下降低了 1.5-2.3%。使用椭圆偏振仪,发现 EBT2 胶片的折射率变化——双折射特性——在 300 和 800cGy 时在 45°(1.72 和 1.71)和 135°(1.8 和 1.77)之间最大。使用分光光度计测量的 EBT2 胶片的吸收光谱是胶片方向的函数。在反射扫描模式下,尽管胶片暴露在室内光下后剂量读数增加,但读数比透射扫描模式更稳定。
透射扫描模式在扫描过程中对胶片方向有很强的依赖性,并且由于室内光的照射导致光密度发生变化,因此,保持恒定的扫描方向和最小的光暴露可以降低测量剂量的不确定性(23±3%)。使用琼斯矩阵分析了角度依赖性,并使用椭圆偏振仪和紫外/可见分光光度计获得了 EBT2 胶片的光学特性。虽然在测量绝对剂量时存在较大的剂量标准偏差,但反射扫描模式相对于室内光和胶片在扫描仪上的方向具有相对较好的稳定性。尽管如此,反射扫描模式在放射治疗中的胶片剂量测量中具有潜在优势,尽管透射扫描模式仍然是首选,因为它提供了更好的不确定性结果。