al-Zaid N S, al-Adnani M S, Gumaa K A
Department of Physiology, Faculty of Medicine, Safat, Kuwait.
Thorax. 1990 Nov;45(11):878-9. doi: 10.1136/thx.45.11.878.
The collagen content of the diaphragm was measured in normal and dystrophic hamsters aged 130 and 270 days. The diaphragm collagen content was greater in dystrophic hamsters than in control hamsters of the same age. The effect was greater in the older hamsters whether the collagen content was expressed in terms of the percentage of dry weight, in relation to surface area, or as total collagen. This increase was apparently at the expense of muscle tissue and may be a major factor contributing to respiratory muscle weakness as dystrophy advances.
在130日龄和270日龄的正常和营养不良仓鼠中测量了膈肌的胶原蛋白含量。营养不良仓鼠的膈肌胶原蛋白含量高于同龄对照仓鼠。无论胶原蛋白含量以干重百分比、相对于表面积还是总胶原蛋白来表示,在老年仓鼠中这种影响都更大。这种增加显然是以肌肉组织为代价的,并且可能是随着营养不良的进展导致呼吸肌无力的一个主要因素。