IRCCS Centro Neurolesi Bonino-Pulejo Messina, Italy.
Epilepsy Behav. 2012 Jun;24(2):283-4. doi: 10.1016/j.yebeh.2012.03.013. Epub 2012 May 3.
The relationship between the older antiepileptic drugs (AEDs) and sexual dysfunction has long been known and it is likely to be related to sexual hormonal changes. Instead, rare reports on sexual disorders related to new AEDs suggest the possibility of complex and poorly understood mechanisms, mainly involving central nervous system neurotransmitters such as glutamate, serotonin, and dopamine. Herein, we describe two young men with epilepsy who experienced severe loss of libido and anhedonia after levetiracetam intake.
老年人抗癫痫药物（AEDs）与性功能障碍之间的关系早已为人所知，这可能与性激素变化有关。相反，关于新型 AEDs 相关性功能障碍的罕见报道表明，可能存在复杂且尚未完全理解的机制，主要涉及中枢神经系统神经递质，如谷氨酸、血清素和多巴胺。在此，我们描述了两名年轻男性癫痫患者，在服用左乙拉西坦后出现严重的性欲减退和快感缺失。
