Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, PR China.
Seizure. 2012 Dec;21(10):807-9. doi: 10.1016/j.seizure.2012.08.008. Epub 2012 Sep 16.
Some antiepileptic drugs (AEDs) have been reported to aggravate generalized seizures. We have seen three children whose myoclonic seizures increased on starting treatment with Levetiracetam. In all seizures aggravation was temporally associated to the introduction of the drug. All became seizure-free on withdrawal of levetiracetam with a switch to an alternative antiepileptic drug and this persisted for at least 6 months. This suggests that some children with myoclonic seizures may have an aggravation on starting treatment with levetiracetam but this requires further studies.
一些抗癫痫药物（AEDs）已被报道可加重全身性发作。我们观察到 3 例患儿在开始使用左乙拉西坦治疗后肌阵挛发作增加。所有病例中，药物的引入与癫痫发作加重均具有时间相关性。所有患儿在停用左乙拉西坦并换用另一种抗癫痫药物后均无癫痫发作，且至少持续 6 个月。这表明，一些肌阵挛性癫痫患儿在开始使用左乙拉西坦治疗时可能会出现病情加重，但这需要进一步研究。
