Hamilton Regional Eye Institute, McMaster University, Hamilton, Ontario, Canada.
Can J Ophthalmol. 2012 Apr;47(2):181-4. doi: 10.1016/j.jcjo.2012.01.024.
To determine the recurrence rates of basal cell carcinoma of the periocular skin in patients who were in the following 3 groups after pathologic analysis: Mohs frozen sections (negative margins); permanent sections with positive tumor margins; and permanent sections with negative tumor margins at the time of primary surgical removal.
The study is a retrospective chart review.
We identified 385 patients who underwent surgery for basal cell carcinoma. The surgery was performed by a single surgeon between January 1, 1995 and January 1, 2005.
The patients were divided into 3 groups: (i) Mohs frozen sections with margins negative for tumor; (ii) permanent sections with margins negative for tumor; (iii) permanent sections with margins positive for tumor. The recurrence rates of basal cell carcinoma were compared.
The recurrence-free rate was 92% for the group that had had Mohs frozen-section, 87% for the group that had had permanent sections with negative margins, and 80% for the group that had had permanent sections with positive margins at 170 months follow-up time. We found that the only predictor of recurrence rate was younger age (hazards ratio (HR) = 0.97 95%; CI 0.94, 0.99; p = 0.021).
The results showed a statistically significant difference in the recurrence-free rate in the 3 groups. A minimum of a 3-year follow-up is recommended in patients who have had basal cell carcinomas removed; the average time to recurrence was approximately 3 years.
确定经病理分析后处于以下 3 组的患者的眼周皮肤基底细胞癌复发率：Mohs 冷冻切片（切缘阴性）；初次手术切除时永久性切片肿瘤切缘阳性；初次手术切除时永久性切片肿瘤切缘阴性。
该研究是一项回顾性图表回顾。
我们确定了 385 名接受基底细胞癌手术的患者。该手术由一位外科医生在 1995 年 1 月 1 日至 2005 年 1 月 1 日之间进行。
患者分为 3 组：（i）Mohs 冷冻切片肿瘤切缘阴性；（ii）永久性切片肿瘤切缘阴性；（iii）永久性切片肿瘤切缘阳性。比较基底细胞癌的复发率。
在 170 个月的随访时间内，Mohs 冷冻切片组的无复发生存率为 92%，永久性切片切缘阴性组为 87%，永久性切片切缘阳性组为 80%。我们发现，唯一预测复发率的因素是年龄较小（风险比（HR）=0.97 95%；CI 0.94, 0.99；p = 0.021）。
结果表明 3 组之间无复发生存率存在统计学显著差异。建议对已切除基底细胞癌的患者进行至少 3 年的随访；平均复发时间约为 3 年。
