The Key Laboratory of Plant Cell Engineering and Germplasm Innovation of Ministry of Education, Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Sciences, Shandong University, Jinan, Shandong 250100, China.
Dev Comp Immunol. 2013 Jan-Feb;39(1-2):27-38. doi: 10.1016/j.dci.2012.04.009. Epub 2012 May 2.
Lectins play important roles in many biological processes, including protein trafficking, cell signaling, pathogen recognition, as effector molecules, and so on, because of their capacity to bind carbohydrates. Presently, seven groups of lectins have been identified in shrimp: C-type, L-type, P-type, M-type, fibrinogen-like domain lectins, galectins, and calnexin/calreticulin. These lectins have different structures, diverse expression patterns, and multiple functions in the shrimp immune response. This review summarizes the research progress and analyzes the diversity of shrimp lectins, focusing mainly on the C-type lectin family. Shrimp C-type lectins show considerable diversity in their domain architectures, sugar substrates, tissue distributions, expression patterns responding to pathogen challenge and functions in shrimp immunity.
凝集素在许多生物学过程中发挥着重要作用，包括蛋白质运输、细胞信号转导、病原体识别、作为效应分子等，这是因为它们能够结合碳水化合物。目前，已在虾中鉴定出七组凝集素：C 型、L 型、P 型、M 型、纤维蛋白原样结构域凝集素、半乳凝集素和钙联蛋白/钙网蛋白。这些凝集素在虾的免疫反应中具有不同的结构、不同的表达模式和多种功能。本综述总结了虾凝集素的研究进展，并分析了虾凝集素的多样性，主要集中在 C 型凝集素家族。虾 C 型凝集素在结构域结构、糖底物、组织分布、对病原体挑战的表达模式以及在虾免疫中的功能方面表现出相当大的多样性。
