Zhang L, van Bree S, van Rood J J, Claas F H
Department of Immunohaematology and Blood bank, University Hospital, Leiden, The Netherlands.
Transplantation. 1990 Dec;50(6):1008-10. doi: 10.1097/00007890-199012000-00022.
In order to study the correlation between HLA mismatches and the cytotoxic T lymphocyte precursor frequency, we used a limiting dilution analysis to determine the CTLp frequencies against individual mismatched HLA-A and -B alloantigens in 21 patients waiting for a renal transplant. Altogether, thirty-three mismatched HLA-A antigens and 55 HLA-B antigens were tested. The CTLp frequencies against mismatches of HLA-B locus antigens were found to be significantly higher than those against HLA-A antigens (P less than 0.002). This may explain why matching for HLA-B antigens is more important for a good renal allograft survival than matching for HLA-A antigens.
为了研究人类白细胞抗原（HLA）错配与细胞毒性T淋巴细胞前体频率之间的相关性，我们采用有限稀释分析法，测定了21例等待肾移植患者针对单个错配的HLA - A和 - B同种异体抗原的细胞毒性T淋巴细胞前体（CTLp）频率。总共检测了33个错配的HLA - A抗原和55个HLA - B抗原。结果发现，针对HLA - B位点抗原错配的CTLp频率显著高于针对HLA - A抗原错配的频率（P < 0.002）。这或许可以解释为什么HLA - B抗原配型对于肾移植良好存活比HLA - A抗原配型更为重要。
