Sabbaj Steffanie, Scanlon Nicholas, Du Victor Y, Wang Yuge, Tang Jianming, Hunter Eric, Goepfert Paul A
Departments of *Medicine; †Microbiology, University of Alabama at Birmingham, Birmingham, AL; and ‡Emory Vaccine Center at Yerkes National Primate Research Center and Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA.
J Acquir Immune Defic Syndr. 2016 Apr 15;71(5):493-7. doi: 10.1097/QAI.0000000000000901.
Epidemiologic studies have demonstrated that HIV-1 discordant couples who share HLA-B alleles were more likely to transmit HIV-1. These data lead us to hypothesize that individuals who match at both HLA-B alleles should have a reduced allogeneic response than those who are not matched. We observed diminished killing of CD4 target cells only when HLA-B alleles were matched. We propose that for cell-associated HIV-1 transmission, the ability of the recipient to eliminate infected cells from a donor partner may be enhanced when HLA-B alleles are different between partners. These findings suggest a novel mechanism for protection against HIV infection.
流行病学研究表明，共享HLA - B等位基因的HIV - 1血清学不一致的伴侣更有可能传播HIV - 1。这些数据使我们推测，在两个HLA - B等位基因上都匹配的个体应该比不匹配的个体具有更低的同种异体反应。我们观察到只有当HLA - B等位基因匹配时，CD4靶细胞的杀伤才会减少。我们提出，对于细胞相关的HIV - 1传播，当伴侣之间的HLA - B等位基因不同时，受体从供体伴侣中清除感染细胞的能力可能会增强。这些发现提示了一种预防HIV感染的新机制。
