Khondker L, Wahab M A, Khan S I
Department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University, Shahbagh, Dhaka, Bangladesh.
Mymensingh Med J. 2012 Apr;21(2):259-64.
The interventional type of study to assess the efficacy of Pimecrolimus cream in the treatment of patient of localized discoid lupus erythematosus (DLE) was carried out for a period of July 2008 to June 2009. It was observed that before treatment, erythema was severe in 43.2% cases, moderate in 51.4% cases and mild type erythema was present in 5.4% cases. The post- treatment revealed, 29.7% severe type erythema, none evidenced moderate type erythema, only 43.2% had mild type and 27% cases no erythema at all. Before treatment, infiltration was severe in 27% cases, moderate in 54.1% cases and only 18.9% had mild type infiltration. But after treatment, 10.8% had severe type infiltration, 18.9% had moderate, 51.4% had mild and 18.9% had no infiltration at all. Similar response to treatment was noticed with squamation which exhibited a drop from 37.8% to 18.9% in severe cases and from 62.2% to 10.8% in moderate cases. There was a 45.9% mild case and 24.3% had no squamation. The scoring result of photosensitivity, itching, disfigurement evidenced analogously score reduction of 2.0, 3.05 and 3.12 respectively. In conclusion, it was interpreted that score of patients of DLE, before treatment was 6.83 ± 1.30 and after treatment was 3.83 ± 1.18. Unpaired 't' test was found statistically significant (p<0.05) between before and after treatment by drug. Improvement was shown in 26(70.27%) cases and 11(29.73%) cases shown no improvement at all. Marked improvement observed on the 2nd follow up visit at the end of 12 weeks. Response was good in 23(88.46%) cases, fair 2(7.69%) and poor 1(3.85%) cases. The study suggests that pimecrolimus 1% cream has significant efficacy profile for treatment option of cutaneous lupus erythematosus.
一项评估吡美莫司乳膏治疗局限性盘状红斑狼疮（DLE）患者疗效的干预性研究于2008年7月至2009年6月进行。观察发现，治疗前，43.2%的病例红斑严重，51.4%的病例红斑中度，5.4%的病例为轻度红斑。治疗后显示，29.7%为重度红斑，无中度红斑病例，仅43.2%为轻度红斑，27%的病例完全无红斑。治疗前，27%的病例浸润严重，54.1%的病例浸润中度，仅18.9%的病例为轻度浸润。但治疗后，10.8%为重度浸润，18.9%为中度，51.4%为轻度，18.9%完全无浸润。鳞屑方面也观察到类似的治疗反应，重度病例从37.8%降至18.9%，中度病例从62.2%降至10.8%。轻度病例占45.9%，24.3%无鳞屑。光敏性、瘙痒、毁容的评分结果分别类似地降低了2.0、3.05和3.12。总之，经解读，DLE患者治疗前评分为6.83±1.30，治疗后为3.83±1.18。药物治疗前后的非配对“t”检验在统计学上具有显著性（p<0.05）。26例（70.27%）病情改善，11例（29.73%）完全无改善。在12周结束时的第二次随访中观察到明显改善。23例（88.46%）反应良好，2例（7.69%）一般，1例（3.85%）较差。该研究表明，1%吡美莫司乳膏对皮肤红斑狼疮的治疗选择具有显著疗效。
