Fariduddin M, Amin A H, Ahmed M U, Karim S S, Moslem F, Kamal M
Head Endocrine Wing (White Unit) Department of Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
Mymensingh Med J. 2012 Apr;21(2):276-80.
Solitary thyroid nodule is a common endocrine problem. The main concern of solitary thyroid nodule lies in excluding the malignancy & to operate on as few patients as possible. Other than history & clinical examination, hormone assessment, USG of thyroid gland, radionuclide scan & FNAC were used to differentiate malignant nodules from benign ones. In this study 127 cases with solitary thyroid nodule of all age group & both sexes were included from Endocrine & Thyroid clinic of BSMMU. They were clinically & biochemically euthyroid & had cold nodule on radionuclide scan. USG & FNAC were done & subsequently they underwent surgical procedure. On the basis of postoperative histopathological report the specimens were divided into benign & malignant groups. All the nodules were cold among which 104 were solid & 23 were mixed in consistency. Of the 104 solid cold nodules histopathology revealed 36(34.6%) malignant & 68(65.4%) benign cases. From the 23 mixed cold solitary nodule 5(21.7%) appeared malignant & 18(78.3%) were benign. So malignancy was higher in solid cold group than the mixed cold one but this was not statistically significant (p=0.673). FNAC was done & it revealed that 83(65.5%) cases were benign, 10(7.8%) cases were suspicious & 34(26.7%) were malignant. Finally histopathology showed 41(32.3%) cases were positive & 86(67.7%) cases were negative for malignancy.
孤立性甲状腺结节是一种常见的内分泌问题。孤立性甲状腺结节的主要关注点在于排除恶性肿瘤，并尽可能减少手术患者数量。除了病史和临床检查外，还采用激素评估、甲状腺超声检查、放射性核素扫描和细针穿刺抽吸活检（FNAC）来区分恶性结节和良性结节。在本研究中，纳入了来自孟加拉国谢赫穆吉布医学大学内分泌与甲状腺诊所的127例各年龄组及男女的孤立性甲状腺结节患者。他们临床和生化指标显示甲状腺功能正常，放射性核素扫描显示为冷结节。进行了超声检查和细针穿刺抽吸活检，随后他们接受了手术。根据术后组织病理学报告，标本被分为良性和恶性组。所有结节均为冷结节，其中104个为实性，23个为混合性。在104个实性冷结节中，组织病理学显示36例（34.6%）为恶性，68例（65.4%）为良性。在23个混合性冷孤立结节中，5例（21.7%）表现为恶性，18例（78.3%）为良性。因此，实性冷结节组的恶性率高于混合性冷结节组，但差异无统计学意义（p = 0.673）。进行了细针穿刺抽吸活检，结果显示83例（65.5%）为良性，10例（7.8%）为可疑，34例（26.7%）为恶性。最后，组织病理学显示41例（32.3%）为恶性阳性，86例（67.7%）为恶性阴性。
