平均血小板体积：甲状腺恶性结节被忽视的早期指标
MEAN PLATELET VOLUME: AN OVERLOOKED HERALD OF MALIGNANT THYROID NODULES.
作者信息
Sit Mustafa, Aktas Gulali, Ozer Bahri, Kocak Mehmet Zahid, Erkus Edip, Erkol Hayri, Yaman Semih, Savli Haluk
机构信息
Abant Izzet Baysal University Hospital, Department of Internal Medicine, Golkoy, Bolu, Turkey.
出版信息
Acta Clin Croat. 2019 Sep;58(3):417-420. doi: 10.20471/acc.2019.58.03.03.
Abstract
Physicians and surgeons pay much attention to evaluating thyroid nodules due to the malignant potential of these growths. Inflammation has a crucial role in the development of cancer. Increase in the mean platelet volume (MPV) has been described in various inflammatory conditions. Since some of thyroid nodules are malignant, we aimed to compare MPV values between patients with malignant and benign thyroid nodules after precise pathologic diagnosis. We retrospectively analyzed hemograms of patients having undergone thyroid surgery for thyroid nodule between January 2013 and January 2015, and compared them to those recorded in healthy subjects. MPV was higher in the malignant thyroid nodule group than in the benign nodule group (9.1±1 fL . 7.8±0.8 fL). The difference was statistically significant (p<0.001). Increased MPV should be considered as an assistive diagnostic tool in differentiating malignant and benign thyroid nodules. However, further prospective studies are required to confirm its usefulness in this population.
摘要
由于甲状腺结节具有恶变潜能，内科医生和外科医生都非常重视对其进行评估。炎症在癌症的发生发展中起着关键作用。在各种炎症状态下均已发现平均血小板体积（MPV）升高。鉴于部分甲状腺结节为恶性，我们旨在对经精确病理诊断的恶性和良性甲状腺结节患者的MPV值进行比较。我们回顾性分析了2013年1月至2015年1月期间因甲状腺结节接受甲状腺手术患者的血常规，并与健康受试者的记录进行比较。恶性甲状腺结节组的MPV高于良性结节组（9.1±1 fL对7.8±0.8 fL）。差异具有统计学意义（p<0.001）。MPV升高应被视为鉴别恶性和良性甲状腺结节的辅助诊断工具。然而，需要进一步的前瞻性研究来证实其在该人群中的实用性。
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