Department of Ophthalmology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA.
Nat Med. 2012 May 4;18(5):658-60. doi: 10.1038/nm.2761.
Age-related macular degeneration (AMD) is the most common cause of blindness in the elderly. AMD progression is associated with alterations in inflammatory pathways and the immune system. A new study identifies a protective role for inflammasomes in AMD, suggesting that inflammasome activation might be manipulated as a potential therapeutic strategy for this condition (pages 791-798).
年龄相关性黄斑变性(AMD)是老年人失明的最常见原因。AMD 的进展与炎症途径和免疫系统的改变有关。一项新的研究确定了炎症小体在 AMD 中的保护作用,表明炎症小体的激活可能被操纵为治疗这种疾病的潜在策略(第 791-798 页)。