Fonseca Nuno A, Vieira Cristina P, Schlötterer Christian, Vieira Jorge
CRACS-INESC Porto LA, Porto, Portugal.
Fly (Austin). 2012 Apr-Jun;6(2):71-4. doi: 10.4161/fly.19423. Epub 2012 Apr 1.
Chromosomal inversions can originate from breakage and repair by non-homologous end-joining. Nevertheless, they can also originate from ectopic recombination between transposable elements located on the same chromosome inserted in opposite orientations. Here, we show that a MITE element (DAIBAM), previously involved in the origin of one Drosophila americana polymorphic inversion, is also involved in the origin of one fixed inversion between D. virilis and D. americana and another D. americana polymorphic inversion. Therefore, DAIBAM is responsible for at least 20% of the chromosomal rearrangements that are observed within and between species of the virilis phylad (D. virilis, D. lummei, D. novamexicana and D. americana), having thus played a significant role in the chromosomal evolution of this group of closely related species.
染色体倒位可源于非同源末端连接的断裂与修复。然而，它们也可源于位于同一条染色体上、以相反方向插入的转座元件之间的异位重组。在此，我们表明，一个先前参与美洲果蝇一个多态性倒位起源的微型反向重复转座元件（DAIBAM），也参与了粗壮果蝇和美洲果蝇之间一个固定倒位以及另一个美洲果蝇多态性倒位的起源。因此，DAIBAM在粗壮果蝇族（粗壮果蝇、卢氏果蝇、新墨西哥果蝇和美洲果蝇）的物种内和物种间观察到的染色体重排中至少占20%，因而在这一组密切相关物种的染色体进化中发挥了重要作用。
