Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, Universidade do Porto, Porto, Portugal.
Drug Discov Today. 2012 Aug;17(15-16):880-9. doi: 10.1016/j.drudis.2012.04.007. Epub 2012 Apr 25.
Formerly regarded purely as passive energy storage, adipose tissue is now recognized as a vital endocrine organ. Adipocytes secrete diverse peptide hormones named adipokines, which act in a autocrine, paracrine or endocrine way to influence several biological functions. Adipokines comprise diverse bioactive substances, including cytokines, growth, and complement factors, which perform essential regulatory functions related to energy balance, satiety and immunity. Presently adipokines have been widely implicated in obesity, diabetes, hypertension and cardiovascular diseases. In this article we aim to present a brief description of the roles and potential therapeutic modulation of adipokines, such as leptin, resistin, adiponectin, apelin, visfatin, FABP-4, tumor necrosis factor-α (TNF-α), interleukin-6 and plasminogen activator inhibitor-1 (PAI-1).
先前被纯粹视为被动储能的脂肪组织，现在被认为是一个重要的内分泌器官。脂肪细胞分泌多种名为脂联素的肽类激素，它们以自分泌、旁分泌或内分泌的方式发挥作用，影响多种生物学功能。脂联素包含多种生物活性物质，包括细胞因子、生长因子和补体因子，这些物质发挥着与能量平衡、饱腹感和免疫力相关的重要调节功能。目前，脂联素已广泛涉及肥胖、糖尿病、高血压和心血管疾病等疾病。本文旨在简要介绍脂联素（如瘦素、抵抗素、脂联素、apelin、内脂素、FABP-4、肿瘤坏死因子-α（TNF-α）、白细胞介素-6 和纤溶酶原激活物抑制剂-1（PAI-1））等脂联素的作用和潜在治疗调节作用。
