Department and Clinic of Animal Surgery, University of Life Sciences in Lublin, Głeboka 30, 20-612 Lublin, Poland.
Department of Pediatric and Adolescent Gynecology, Medical University of Lublin, Chodzki 4, 20-094 Lublin, Poland.
Int J Mol Sci. 2023 Dec 22;25(1):205. doi: 10.3390/ijms25010205.
Chronic tendon and ligament diseases are commonly encountered in both athletic humans and animals, especially horses. Distal limb diseases, including suspensory ligament (SL) pathology due to anatomical, histological, and biomechanical properties, can be considered a model for tendon and ligament pathologies in humans. The appropriate selection of therapy is often crucial in optimising the healing process. One decisive factor influencing the possibility of returning to pre-disease training levels appears to be the utilisation of physical activity, including controlled movement, during the rehabilitation process. In the pathogenesis of musculoskeletal diseases and rehabilitation, adipocytokines play diverse roles. However, it is unclear what significance they hold in horses and in specific disease entities as well as the consequences of their mutual interactions. Recent studies indicate that in the pathogenesis of diseases with varied aetiologies in humans, their value varies at different stages, resulting in a diverse response to treatment. The results of this study demonstrate lower resistin concentrations in the venous blood plasma of horses with proximal suspensory desmopathy (PSD), while higher levels were observed in regularly trained and paddocked animals. The horses investigated in this study showed higher concentrations of resistin and IL-8, particularly in paddocked horses as well as in the working group of horses. The results suggest that these concentrations, including resistin in blood plasma, may be clinically significant. This attempt to explore the aetiopathogenesis of the processes occurring in the area of the proximal attachment of the suspensory ligament may optimise the procedures for the treatment and rehabilitation of horses.
慢性肌腱和韧带疾病在运动员和动物中都很常见，尤其是马。四肢疾病，包括由于解剖学、组织学和生物力学特性引起的悬韧带（SL）病变，可被视为人类肌腱和韧带疾病的模型。选择适当的治疗方法通常对优化愈合过程至关重要。影响恢复到疾病前训练水平可能性的一个决定性因素似乎是在康复过程中利用体育活动，包括受控运动。在肌肉骨骼疾病和康复的发病机制中，脂肪细胞因子发挥着多种作用。然而，它们在马和特定疾病实体中的重要性以及它们相互作用的后果尚不清楚。最近的研究表明，在人类不同病因疾病的发病机制中，它们的价值在不同阶段有所不同，导致对治疗的反应不同。这项研究的结果表明，患有近端悬韧带病（PSD）的马静脉血浆中的抵抗素浓度较低，而经常接受训练和在围场中饲养的动物则较高。本研究中调查的马表现出更高浓度的抵抗素和 IL-8，尤其是在围场饲养的马和工作马群中。这些结果表明，这些浓度，包括血浆中的抵抗素，可能具有临床意义。这种探索发生在悬韧带近端附着区的发病机制的尝试可能会优化马的治疗和康复程序。
