Department of Pharmaceutical Technology, University of Innsbruck, Innsbruck, Austria.
Eur J Pharm Biopharm. 2012 Aug;81(3):463-9. doi: 10.1016/j.ejpb.2012.04.007. Epub 2012 Apr 26.
Within the past 20 years, a considerable amount of work has been published on chitosan and its potential use in drug delivery systems. In contrast to all other polysaccharides having a monograph in a pharmacopeia, chitosan has a cationic character because of its primary amino groups. These primary amino groups are responsible for properties such as controlled drug release, mucoadhesion, in situ gellation, transfection, permeation enhancement, and efflux pump inhibitory properties. Due to chemical modifications, most of these properties can even be further improved. Within this review, an overview on the advantages of chitosan for various types of drug delivery systems is provided.
在过去的 20 年中，已经发表了相当数量的关于壳聚糖及其在药物传递系统中的潜在用途的工作。与所有其他在药典中有专论的多糖不同，由于其伯氨基，壳聚糖具有阳离子特性。这些伯氨基负责控制药物释放、粘膜粘附、原位凝胶形成、转染、渗透增强和外排泵抑制等特性。由于化学修饰，其中的大多数特性甚至可以进一步改善。在这篇综述中，概述了壳聚糖在各种类型的药物传递系统中的优势。
