Sanjaykumar Swati Gupta, Malviya Rishabha, Srivastava Saurabh, Ahmad Irfan, Uniyal Prerna, Singh Bhupinder, Nisar Nazima
Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, U.P., India.
School of Pharmacy, KPJ Healthcare University College, Nilai, Malaysia.
Curr Protein Pept Sci. 2025;26(3):185-200. doi: 10.2174/0113892037323136240910052119.
One of the most well-known instances of an interdisciplinary subject is tissue engineering, where experts from many backgrounds collaborate to address important health issues and improve people's quality of life. Many researchers are interested in using chitosan and its derivatives as an alternative to fabricating scaffold engineering and skin grafts in tissue because of its natural abundance, affordability, biodegradability, biocompatibility, and wound healing properties. Nanomaterials based on peptides can provide cells with the essential biological cues required to promote cellular adhesion and are easily fabricated. Due to such worthy properties of chitosan and peptide, they find their application in tissue engineering and regeneration processes. The implementation of hybrids of chitosan and peptide is increasing in the field of tissue engineering and scaffolding for improved cellular adherence and bioactivity. This review covers the individual applications of peptide and chitosan in tissue engineering and further discusses the role of their conjugates in the same. Here, the recent findings are also discussed, along with studies involving the use of these hybrids in tissue engineering applications.
跨学科主题最著名的例子之一是组织工程,来自许多背景的专家在此领域合作,以解决重要的健康问题并提高人们的生活质量。由于壳聚糖及其衍生物天然丰富、价格低廉、可生物降解、具有生物相容性以及伤口愈合特性,许多研究人员对将其用作组织中制造支架工程和皮肤移植物的替代品感兴趣。基于肽的纳米材料可以为细胞提供促进细胞粘附所需的基本生物信号,并且易于制造。由于壳聚糖和肽具有这些有价值的特性,它们在组织工程和再生过程中得到了应用。壳聚糖和肽的杂化物在组织工程和支架领域的应用正在增加,以改善细胞粘附和生物活性。本文综述了肽和壳聚糖在组织工程中的各自应用,并进一步讨论了它们的结合物在其中的作用。此外,还讨论了最近的研究结果以及涉及在组织工程应用中使用这些杂化物的研究。