老年期抑郁症的生物学基础。
Biological basis of late life depression.
机构信息
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
出版信息
Curr Psychiatry Rep. 2012 Aug;14(4):273-9. doi: 10.1007/s11920-012-0279-6.
Abstract
Late life depression (LLD) is an important area of research given the growing elderly population. The purpose of this review is to examine the available evidence for the biological basis of LLD. Structural neuroimaging shows specific gray matter structural changes in LLD as well as ischemic lesion burden via white matter hyperintensities. Similarly, specific neuropsychological deficits have been found in LLD. An inflammatory response is another possible underlying contributor to the pathophysiology of LLD. We review the available literature examining these multiple facets of LLD and how each may affect clinical outcome in the depressed elderly.
摘要
随着老年人口的增长，晚年抑郁症（LLD）是一个重要的研究领域。本综述的目的是探讨 LLD 的生物学基础的现有证据。结构神经影像学显示 LLD 存在特定的灰质结构变化以及通过白质高信号的缺血性病变负担。同样，LLD 也存在特定的神经心理学缺陷。炎症反应是 LLD 病理生理学的另一个潜在因素。我们回顾了现有的文献，探讨了 LLD 的这些多方面及其如何影响老年抑郁患者的临床预后。
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本文引用的文献
1
MRI High-Intensity Signals in Late-Life Depression and Alzheimer's Disease: A Comparison of Subjects Without Major Vascular Risk Factors.
Am J Geriatr Psychiatry. 1994;2(4):332-337. doi: 10.1097/00019442-199402040-00008. Epub 2013 Jan 28.
2
Exploring the pattern and neural correlates of neuropsychological impairment in late-life depression.探讨老年期抑郁症患者神经心理学损伤的模式和神经相关因素。
Psychol Med. 2012 Jun;42(6):1195-202. doi: 10.1017/S0033291711002352. Epub 2011 Oct 26.
3
Amygdala volume in late-life depression: relationship with age of onset.老年期抑郁症的杏仁核体积：与发病年龄的关系。
Am J Geriatr Psychiatry. 2011 Sep;19(9):771-6. doi: 10.1097/JGP.0b013e318211069a.
4
MRI signal hyperintensities and failure to remit following antidepressant treatment.MRI 信号高信号和抗抑郁治疗后未能缓解。
J Affect Disord. 2011 Dec;135(1-3):315-20. doi: 10.1016/j.jad.2011.06.052. Epub 2011 Jul 29.
5
Cognitive functioning and the natural course of depressive symptoms in late life.认知功能与老年人抑郁症状的自然病程。
Am J Geriatr Psychiatry. 2011 Jul;19(7):664-72. doi: 10.1097/JGP.0b013e3181f7d8e9.
6
Depressive symptoms, brain volumes and subclinical cerebrovascular disease in postmenopausal women: the Women's Health Initiative MRI Study.绝经后妇女的抑郁症状、脑容量与亚临床脑血管病：妇女健康倡议 MRI 研究。
J Affect Disord. 2011 Jul;132(1-2):275-84. doi: 10.1016/j.jad.2011.01.020. Epub 2011 Feb 24.
7
Neuroanatomical and neuropsychological features of elderly euthymic depressed patients with early- and late-onset.老年单相抑郁患者早发和晚发与神经解剖和神经心理学特征。
J Neurol Sci. 2010 Dec 15;299(1-2):19-23. doi: 10.1016/j.jns.2010.08.046. Epub 2010 Sep 17.
8
MRI signal hyperintensities and treatment remission of geriatric depression.MRI 信号高信号与老年抑郁症的治疗缓解。
J Affect Disord. 2010 Nov;126(3):395-401. doi: 10.1016/j.jad.2010.04.004. Epub 2010 May 7.
9
Support for the vascular depression hypothesis in late-life depression: results of a 2-site, prospective, antidepressant treatment trial.老年期抑郁症血管性抑郁假说的支持证据：一项双中心、前瞻性抗抑郁治疗试验的结果
Arch Gen Psychiatry. 2010 Mar;67(3):277-85. doi: 10.1001/archgenpsychiatry.2009.204.
10
Depressive symptoms and brain volumes in older adults: a longitudinal magnetic resonance imaging study.老年人的抑郁症状与脑容量：一项纵向磁共振成像研究
J Psychiatry Neurosci. 2009 Sep;34(5):367-75.
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