• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Molecular design of O-phosphorylated oximes--selective inhibitors of butyrylcholinesterase.

作者信息

Radchenko E V, Mel'nikov A A, Makhaeva G F, Palyulin V A, Zefirov N S

机构信息

Department of Chemistry, Moscow State University, Moscow, 119991 Russia.

出版信息

Dokl Biochem Biophys. 2012 Mar-Apr;443:91-5. doi: 10.1134/S1607672912020093. Epub 2012 May 5.

DOI:10.1134/S1607672912020093
PMID:22562633
Abstract
摘要

相似文献

1
Molecular design of O-phosphorylated oximes--selective inhibitors of butyrylcholinesterase.
Dokl Biochem Biophys. 2012 Mar-Apr;443:91-5. doi: 10.1134/S1607672912020093. Epub 2012 May 5.
2
Modeling of the relationships between the structure of O-phosphorylated oximes and their anticholinesterase activity and selectivity using molecular field topology analysis (MFTA).利用分子场拓扑分析（MFTA）对O-磷酸化肟的结构与其抗胆碱酯酶活性和选择性之间的关系进行建模。
Dokl Biochem Biophys. 2008 Jan-Feb;418:47-51. doi: 10.1134/s1607672908010122.
3
Tryptoline-3-hydroxypyridinaldoxime conjugates as efficient reactivators of phosphylated human acetyl and butyrylcholinesterases.色胺酮-3-羟基吡啶醛肟共轭物作为磷酸化人乙酰胆碱酯酶和丁酰胆碱酯酶的有效重活化剂。
Chem Commun (Camb). 2014 Apr 18;50(30):3947-50. doi: 10.1039/c4cc00561a. Epub 2014 Mar 5.
4
Mechanistic studies of new oximes reactivators of human butyryl cholinesterase inhibited by cyclosarin and sarin.环沙林和沙林抑制人丁酰胆碱酯酶的新型肟类重活化剂的作用机制研究
J Biomol Struct Dyn. 2017 May;35(6):1272-1282. doi: 10.1080/07391102.2016.1178173. Epub 2016 Jun 7.
5
Structure-activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabun.塔崩类似物抑制的人丁酰胆碱酯酶衰老与复活的构效关系分析
Biochem J. 2009 Jun 12;421(1):97-106. doi: 10.1042/BJ20090091.
6
Pseudo-catalytic scavenging: searching for a suitable reactivator of phosphorylated butyrylcholinesterase.假性催化清除：寻找合适的磷酸化丁酰胆碱酯酶重活化剂。
Chem Biol Interact. 2010 Sep 6;187(1-3):167-71. doi: 10.1016/j.cbi.2010.02.023. Epub 2010 Mar 3.
7
Reactivation kinetics of 31 structurally different bispyridinium oximes with organophosphate-inhibited human butyrylcholinesterase.31种结构不同的双吡啶肟与有机磷酸酯抑制的人丁酰胆碱酯酶的重新激活动力学
Arch Toxicol. 2015 Mar;89(3):405-14. doi: 10.1007/s00204-014-1288-5. Epub 2014 Jun 11.
8
Butyrylcholinesterase inhibited by nerve agents is efficiently reactivated with chlorinated pyridinium oximes.神经毒剂抑制的丁酰胆碱酯酶可以被氯代吡啶酮肟类化合物有效重激活。
Chem Biol Interact. 2019 Jul 1;307:16-20. doi: 10.1016/j.cbi.2019.04.020. Epub 2019 Apr 18.
9
Discovery and Structure-Activity Relationships of a Highly Selective Butyrylcholinesterase Inhibitor by Structure-Based Virtual Screening.基于结构的虚拟筛选发现高选择性丁酰胆碱酯酶抑制剂及其构效关系
J Med Chem. 2016 Aug 25;59(16):7683-9. doi: 10.1021/acs.jmedchem.6b00356. Epub 2016 Jul 26.
10
Molecular Modeling Studies on the Multistep Reactivation Process of Organophosphate-Inhibited Acetylcholinesterase and Butyrylcholinesterase.多步骤重活化过程的分子建模研究 有机磷抑制的乙酰胆碱酯酶和丁酰胆碱酯酶。
Biomolecules. 2021 Jan 27;11(2):169. doi: 10.3390/biom11020169.

引用本文的文献

1
Powerful Potential of Polyfluoroalkyl-Containing 4-Arylhydrazinylidenepyrazol-3-ones for Pharmaceuticals.含多氟烷基的 4-芳基腙基吡唑-3-酮在药物方面的巨大潜力。
Molecules. 2022 Dec 21;28(1):59. doi: 10.3390/molecules28010059.

本文引用的文献

1
Motor neuron disease due to neuropathy target esterase mutation: enzyme analysis of fibroblasts from human subjects yields insights into pathogenesis.神经病变靶酯酶突变导致的运动神经元病：对人类受试者成纤维细胞的酶分析为发病机制提供了新见解。
Toxicol Lett. 2010 Nov 10;199(1):1-5. doi: 10.1016/j.toxlet.2010.06.020. Epub 2010 Sep 17.
2
Study of the structural determinants of acute and delayed neurotoxicity of O-phosphorylated oximes by molecular field topology analysis (MFTA).通过分子场拓扑分析（MFTA）研究O-磷酸化肟类化合物急性和迟发性神经毒性的结构决定因素。
Dokl Biochem Biophys. 2009 Nov-Dec;429:309-14. doi: 10.1134/s1607672909060064.
3
Esterase profile and analysis of structure-inhibitor selectivity relationships for homologous phosphorylated 1-hydroperfluoroisopropanols.
同源磷酸化1-氢全氟异丙醇的酯酶谱及结构-抑制剂选择性关系分析
Dokl Biochem Biophys. 2008 Nov-Dec;423:352-7. doi: 10.1134/s1607672908060094.
4
Modeling of the relationships between the structure of O-phosphorylated oximes and their anticholinesterase activity and selectivity using molecular field topology analysis (MFTA).利用分子场拓扑分析（MFTA）对O-磷酸化肟的结构与其抗胆碱酯酶活性和选择性之间的关系进行建模。
Dokl Biochem Biophys. 2008 Jan-Feb;418:47-51. doi: 10.1134/s1607672908010122.
5
Cholinesterase inhibitors: new roles and therapeutic alternatives.胆碱酯酶抑制剂：新作用及治疗选择
Pharmacol Res. 2004 Oct;50(4):433-40. doi: 10.1016/j.phrs.2003.11.017.
6
Selectivity fields: comparative molecular field analysis (CoMFA) of the glycine/NMDA and AMPA receptors.选择性场：甘氨酸/N-甲基-D-天冬氨酸受体和α-氨基-3-羟基-5-甲基-4-异恶唑丙酸受体的比较分子场分析
J Med Chem. 2003 Sep 11;46(19):4063-9. doi: 10.1021/jm030833a.
7
Assessment of the neurotoxic potential of some methyl- and phenylphosphonates using a stable preparation of neuropathy target esterase from chicken brain.利用鸡脑制备的稳定的神经病变靶酯酶评估某些甲基膦酸酯和苯基膦酸酯的神经毒性潜力。
Dokl Biochem Biophys. 2001 Mar-Apr;377:68-71. doi: 10.1023/a:1011515320263.
8
Molecular field Topology analysis method in QSAR studies of organic compounds.有机化合物定量构效关系研究中的分子场拓扑分析方法。
J Chem Inf Comput Sci. 2000 May;40(3):659-67. doi: 10.1021/ci980114i.
9
Comparative studies of O,O-dialkyl-O-chloromethylchloroformimino phosphates: interaction with neuropathy target esterase and acetylcholinesterase.O,O-二烷基-O-氯甲基氯代甲亚胺基磷酸酯的比较研究：与神经病变靶酯酶和乙酰胆碱酯酶的相互作用
Neurotoxicology. 1998 Aug-Oct;19(4-5):623-8.