Molecular design of O-phosphorylated oximes--selective inhibitors of butyrylcholinesterase.

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作者信息

Radchenko E V, Mel'nikov A A, Makhaeva G F, Palyulin V A, Zefirov N S

机构信息

Department of Chemistry, Moscow State University, Moscow, 119991 Russia.

出版信息

Dokl Biochem Biophys. 2012 Mar-Apr;443:91-5. doi: 10.1134/S1607672912020093. Epub 2012 May 5.

DOI:10.1134/S1607672912020093

PMID:22562633

Abstract

摘要

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Toxicol Lett. 2010 Nov 10;199(1):1-5. doi: 10.1016/j.toxlet.2010.06.020. Epub 2010 Sep 17.

Study of the structural determinants of acute and delayed neurotoxicity of O-phosphorylated oximes by molecular field topology analysis (MFTA).通过分子场拓扑分析（MFTA）研究O-磷酸化肟类化合物急性和迟发性神经毒性的结构决定因素。

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Esterase profile and analysis of structure-inhibitor selectivity relationships for homologous phosphorylated 1-hydroperfluoroisopropanols.同源磷酸化1-氢全氟异丙醇的酯酶谱及结构-抑制剂选择性关系分析

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Cholinesterase inhibitors: new roles and therapeutic alternatives.胆碱酯酶抑制剂：新作用及治疗选择

Pharmacol Res. 2004 Oct;50(4):433-40. doi: 10.1016/j.phrs.2003.11.017.

Selectivity fields: comparative molecular field analysis (CoMFA) of the glycine/NMDA and AMPA receptors.选择性场：甘氨酸/N-甲基-D-天冬氨酸受体和α-氨基-3-羟基-5-甲基-4-异恶唑丙酸受体的比较分子场分析

J Med Chem. 2003 Sep 11;46(19):4063-9. doi: 10.1021/jm030833a.

Assessment of the neurotoxic potential of some methyl- and phenylphosphonates using a stable preparation of neuropathy target esterase from chicken brain.利用鸡脑制备的稳定的神经病变靶酯酶评估某些甲基膦酸酯和苯基膦酸酯的神经毒性潜力。

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J Chem Inf Comput Sci. 2000 May;40(3):659-67. doi: 10.1021/ci980114i.

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