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Study of the structural determinants of acute and delayed neurotoxicity of O-phosphorylated oximes by molecular field topology analysis (MFTA).

作者信息

Radchenko E V, Makhaeva G F, Sokolov V B, Palyulin V A, Zefirov N S

机构信息

Moscow State University, Moscow, 119991 Russia.

出版信息

Dokl Biochem Biophys. 2009 Nov-Dec;429:309-14. doi: 10.1134/s1607672909060064.

DOI:10.1134/s1607672909060064
PMID:20101827
Abstract
摘要

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Molecular design of O-phosphorylated oximes--selective inhibitors of butyrylcholinesterase.
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本文引用的文献

1
Esterase profile and analysis of structure-inhibitor selectivity relationships for homologous phosphorylated 1-hydroperfluoroisopropanols.同源磷酸化1-氢全氟异丙醇的酯酶谱及结构-抑制剂选择性关系分析
Dokl Biochem Biophys. 2008 Nov-Dec;423:352-7. doi: 10.1134/s1607672908060094.
2
Modeling of the relationships between the structure of O-phosphorylated oximes and their anticholinesterase activity and selectivity using molecular field topology analysis (MFTA).利用分子场拓扑分析（MFTA）对O-磷酸化肟的结构与其抗胆碱酯酶活性和选择性之间的关系进行建模。
Dokl Biochem Biophys. 2008 Jan-Feb;418:47-51. doi: 10.1134/s1607672908010122.
3
Quantitative structure-activity relationships predict the delayed neurotoxicity potential of a series of O-alkyl-O-methylchloroformimino phenylphosphonates.
定量构效关系预测了一系列O-烷基-O-甲基氯亚氨基苯基膦酸酯的迟发性神经毒性潜力。
J Toxicol Environ Health A. 2003 Apr 11;66(7):611-25. doi: 10.1080/15287390309353770.
4
Assessment of the neurotoxic potential of some methyl- and phenylphosphonates using a stable preparation of neuropathy target esterase from chicken brain.利用鸡脑制备的稳定的神经病变靶酯酶评估某些甲基膦酸酯和苯基膦酸酯的神经毒性潜力。
Dokl Biochem Biophys. 2001 Mar-Apr;377:68-71. doi: 10.1023/a:1011515320263.
5
QSAR for the organophosphate-induced inhibition and 'aging' of the enzyme neuropathy target esterase (NTE).有机磷酸酯诱导的神经病变靶酯酶（NTE）抑制和“老化”的定量构效关系
SAR QSAR Environ Res. 2001;12(3):275-95. doi: 10.1080/10629360108032917.
6
Molecular field Topology analysis method in QSAR studies of organic compounds.有机化合物定量构效关系研究中的分子场拓扑分析方法。
J Chem Inf Comput Sci. 2000 May;40(3):659-67. doi: 10.1021/ci980114i.
7
Comparative studies of O,O-dialkyl-O-chloromethylchloroformimino phosphates: interaction with neuropathy target esterase and acetylcholinesterase.O,O-二烷基-O-氯甲基氯代甲亚胺基磷酸酯的比较研究：与神经病变靶酯酶和乙酰胆碱酯酶的相互作用
Neurotoxicology. 1998 Aug-Oct;19(4-5):623-8.
8
Neuropathy target esterase (NTE) and organophosphorus-induced delayed polyneuropathy (OPIDP): recent advances.神经病靶酯酶（NTE）与有机磷诱导的迟发性多发性神经病（OPIDP）：最新进展
Toxicol Lett. 1995 Dec;82-83:459-63. doi: 10.1016/0378-4274(95)03495-1.