Shkliar M B, Soleĭko M B, Alekseeva I P, Kul'chevich L V
Vrach Delo. 1990 Aug(8):13-5.
A study is presented of 51 patients with ischemic heart disease showing stenocardia of functional classes II-III. The patients received verapamil in suppositories. Cessation or reduced of the frequency of stenocardia attacks were noted after a 10-day course of verapamil (dose--40 mg 3 times daily) in 98.1% of patients. The effect of verapamil treatment was more pronounced in angina pectoris without myocardial infarction in the anamnesis. In IHD patients arterial pressure reduced due to decrease of the general peripheral resistance while the cardiac ejection remained unchanged. The antiarrhythmic effect was more pronounced in atrial extrasystole. Side-effects due to verapamil treatment were not registered.
对51例患有功能性II - III级心绞痛的缺血性心脏病患者进行了一项研究。这些患者接受了维拉帕米栓剂治疗。在接受为期10天的维拉帕米疗程(剂量为每日3次,每次40毫克)后,98.1%的患者心绞痛发作频率停止或降低。维拉帕米治疗的效果在既往无心肌梗死的心绞痛患者中更为明显。在缺血性心脏病患者中,由于总外周阻力降低,动脉血压下降,而心脏射血保持不变。抗心律失常作用在房性早搏中更为明显。未记录到维拉帕米治疗的副作用。