Clin Bénédicte, Andujar Pascal, Abd Al Samad Issam, Azpitarte Chantal, Le Pimpec-Barthes Françoise, Billon-Galland Marie-Annick, Danel Claire, Galateau-Salle Françoise, Housset Bruno, Legrand-Cattan Karinne, Matrat Mireille, Monnet Isabelle, Riquet Marc, Pairon Jean-Claude
Institut National de la Santé et de la Recherche Médicale, U955, Equipe 4, Créteil 94000, France.
Ann Occup Hyg. 2012 Aug;56(7):789-95. doi: 10.1093/annhyg/mes017. Epub 2012 May 4.
The hypothesis that asbestos exposure may have more specific associations with particular histological types of lung cancer remains controversial. The aim of this study was to analyze the relationships between asbestos exposure and pulmonary carcinoid tumors.
A retrospective case-control study was conducted in 28 cases undergoing surgery for pulmonary carcinoid tumors and aged >40 years and in 56 controls with lung cancer of a different histological type, matched for gender and age, from 1994 to 1999, recruited in two hospitals in the region of Paris. Asbestos exposure was assessed via expertise of a standardized occupational questionnaire and mineralogical analysis of lung tissue, with quantification of asbestos bodies (AB).
Definite asbestos exposure was identified in 25% of cases and 14% of controls (ns). Cumulative asbestos exposure was significantly higher in cases than in controls (P < 0.05), and results of the quantification of AB tended to be higher in cases than in controls (24 and 9% had >1000 AB per gram dry lung tissue, respectively, P = 0.09). Mean cumulative smoking was lower in cases than in controls (P < 0.05).
This study argues in favor of a relationship between asbestos exposure and certain pulmonary carcinoid tumors.
石棉暴露可能与特定组织学类型的肺癌存在更特定关联这一假说仍存在争议。本研究的目的是分析石棉暴露与肺类癌肿瘤之间的关系。
1994年至1999年在巴黎地区的两家医院进行了一项回顾性病例对照研究，纳入28例年龄大于40岁接受肺类癌肿瘤手术的患者以及56例不同组织学类型肺癌的对照者，根据性别和年龄进行匹配。通过标准化职业问卷评估和肺组织矿物学分析并对石棉小体（AB）进行定量来评估石棉暴露情况。
25%的病例和14%的对照者被确定有明确的石棉暴露（无显著性差异）。病例组的累积石棉暴露显著高于对照组（P < 0.05），且病例组石棉小体定量结果往往高于对照组（每克干肺组织中分别有24%和9%的石棉小体>1000个，P = 0.09）。病例组的平均累积吸烟量低于对照组（P < 0.05）。
本研究支持石棉暴露与某些肺类癌肿瘤之间存在关联。
