镰状细胞病中的红细胞同种免疫：病理生理学、危险因素及输血管理
Red blood cell alloimmunization in sickle cell disease: pathophysiology, risk factors, and transfusion management.
作者信息
Yazdanbakhsh Karina, Ware Russell E, Noizat-Pirenne France
机构信息
Laboratory of Complement Biology, New York Blood Center, 310 East 67th St, NewYork, NY 10065, USA.
出版信息
Blood. 2012 Jul 19;120(3):528-37. doi: 10.1182/blood-2011-11-327361. Epub 2012 May 4.
Abstract
Red blood cell transfusions have reduced morbidity and mortality for patients with sickle cell disease. Transfusions can lead to erythrocyte alloimmunization, however, with serious complications for the patient including life-threatening delayed hemolytic transfusion reactions and difficulty in finding compatible units, which can cause transfusion delays. In this review, we discuss the risk factors associated with alloimmunization with emphasis on possible mechanisms that can trigger delayed hemolytic transfusion reactions in sickle cell disease, and we describe the challenges in transfusion management of these patients, including opportunities and emerging approaches for minimizing this life-threatening complication.
摘要
红细胞输血降低了镰状细胞病患者的发病率和死亡率。然而，输血可导致红细胞同种免疫，给患者带来严重并发症，包括危及生命的迟发性溶血性输血反应以及难以找到相容血源，这可能导致输血延迟。在本综述中，我们讨论了与同种免疫相关的危险因素，重点关注可能引发镰状细胞病迟发性溶血性输血反应的潜在机制，并描述了这些患者输血管理中的挑战，包括减少这种危及生命并发症的机会和新出现的方法。
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J Natl Med Assoc. 2008 Aug;100(8):948-951. doi: 10.1016/S0027-9684(15)31410-3.
2
Transfusion in the absence of inflammation induces antigen-specific tolerance to murine RBCs.在无炎症的情况下输血会诱导对鼠 RBC 的抗原特异性耐受。
Blood. 2012 Feb 9;119(6):1566-9. doi: 10.1182/blood-2011-09-382655. Epub 2011 Nov 10.
3
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Transfusion. 2012 May;52(5):1050-61. doi: 10.1111/j.1537-2995.2011.03416.x. Epub 2011 Nov 2.
4
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