镰状细胞病患者使用全身性皮质类固醇激素相关的严重血管闭塞性发作
Severe Vaso-Occlusive Episodes Associated with Use of Systemic Corticosteroids in Patients with Sickle Cell Disease.
作者信息
Darbari Deepika S, Fasano Ros S, Minniti Caterina P, Castro Oswald O, Gordeuk Victor R, Taylor James G, Rehm Jeffre Y
机构信息
Center for Cancer and Blood Disorders, Children's National Medical Center, Washington, DC.
Center for Cancer and Blood Disorders, Children's National Medical Center, Washington, DC.
出版信息
J Natl Med Assoc. 2008 Aug;100(8):948-951. doi: 10.1016/S0027-9684(15)31410-3.
Abstract
Patients with sickle cell disease (SCD) are occasionally prescribed systemic corticosteroids to treat steroid-responsive conditions. Additionally, use of systemic corticosteroids for sickle cell pain episodes and acute chest syndrome is under investigation. We report 4 patients with SCD who developed severe vaso-occlusive events following the administration of systemic steroids. We also review similar cases from the literature and suggest measures for reducing the potential risk associated with use of systemic corticosteroids in this group of patients. We conclude that corticosteroids should be used with caution in patients with SCD.
摘要
镰状细胞病（SCD）患者偶尔会被处方全身性皮质类固醇来治疗对类固醇有反应的病症。此外，全身性皮质类固醇用于镰状细胞疼痛发作和急性胸综合征的研究正在进行中。我们报告了4例SCD患者，他们在使用全身性类固醇后发生了严重的血管闭塞事件。我们还回顾了文献中的类似病例，并提出了降低该组患者使用全身性皮质类固醇相关潜在风险的措施。我们得出结论，SCD患者应谨慎使用皮质类固醇。
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