Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden.
Blood. 2012 Jun 14;119(24):5879-87. doi: 10.1182/blood-2012-01-407825. Epub 2012 May 4.
Despite decades of research on wound healing, effective biologic agents for the treatment of chronic wounds, especially diabetic wounds, are still lacking. In the present study, we report that the inert plasma protein plasminogen (plg) acts as a key regulatory molecule that potentiates wound healing in mice. Early in the healing process, plg bound to inflammatory cells is transported to the wound area, where the level of plg is increased locally, leading to the induction of cytokines and intracellular signaling events and to a potentiation of the early inflammatory response. Systemic administration of additional plg not only accelerates the healing of acute burn wounds in wild-type mice, but also improves the healing of chronic diabetic wounds in a mouse model of diabetes. Our results suggest that the administration of plg may be a novel therapeutic strategy to treat many different types of wounds, especially chronic wounds such as those caused by diabetes.
尽管在伤口愈合方面已经进行了几十年的研究，但仍然缺乏有效的生物制剂来治疗慢性伤口，尤其是糖尿病伤口。在本研究中，我们报告称，惰性血浆蛋白纤溶酶原（plg）作为一种关键的调节分子，可增强小鼠的伤口愈合能力。在愈合早期，与炎症细胞结合的 plg 被运送到伤口部位，局部 plg 水平升高，导致细胞因子和细胞内信号事件的诱导，并增强早期炎症反应。全身性给予额外的 plg 不仅加速了野生型小鼠急性烧伤伤口的愈合，而且改善了糖尿病小鼠模型中慢性糖尿病伤口的愈合。我们的研究结果表明，给予 plg 可能是治疗多种不同类型伤口的一种新的治疗策略，尤其是糖尿病等慢性伤口。
