人类细胞色素 P450 酶：弗雷德里克·彼得·顾恩里奇的工作。

Human cytochrome P450s: the work of Frederick Peter Guengerich.

出版信息

J Biol Chem. 2012 May 4;287(19):15798-800. doi: 10.1074/jbc.O112.000003.

DOI:10.1074/jbc.O112.000003

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3346133/

Abstract

Purification and Characterization of the Human Liver Cytochromes P-450 Involved in Debrisoquine 4-Hydroxylation and Phenacetin -Deethylation, Two Prototypes for Genetic Polymorphism in Oxidative Drug Metabolism (Distlerath, L. M., Reilly, P. E. B., Martin, M. V., Davis, G. G., Wilkinson, G. R., and Guengerich, F. P. (1985) 260, 9057–9067) Human Liver Microsomal Cytochrome P-450 Mephenytoin 4-Hydroxylase, a Prototype of Genetic Polymorphism in Oxidative Drug Metabolism. Purification and Characterization of Two Similar Forms Involved in the Reaction (Shimada, T., Misono, K. S., and Guengerich, F. P. (1986) 261, 909–921) Characterization of Rat and Human Liver Microsomal Cytochrome P-450 Forms Involved in Nifedipine Oxidation, a Prototype for Genetic Polymorphism in Oxidative Drug Metabolism (Guengerich, F. P., Martin, M. V., Beaune, P. H., Kremers, P., Wolff, T., and Waxman, D. J. (1986) 261, 5051–5060)

摘要

人肝细胞色素 P-450 的纯化和特性研究，这些 P-450 涉及到异喹胍 4-羟化和非那西汀去乙基化反应，这两种反应是氧化药物代谢中遗传多态性的典型范例 (Distlerath, L. M., Reilly, P. E. B., Martin, M. V., Davis, G. G., Wilkinson, G. R., and Guengerich, F. P. (1985) 260, 9057–9067)。人肝微粒体细胞色素 P-450 美芬妥因 4-羟化酶，是氧化药物代谢中遗传多态性的典型范例。两种相似形式的纯化和特性研究，这两种形式都参与了反应 (Shimada, T., Misono, K. S., and Guengerich, F. P. (1986) 261, 909–921)。鉴定大鼠和人肝微粒体细胞色素 P-450 参与硝苯地平氧化的形式，这是氧化药物代谢中遗传多态性的典型范例 (Guengerich, F. P., Martin, M. V., Beaune, P. H., Kremers, P., Wolff, T., and Waxman, D. J. (1986) 261, 5051–5060)。