Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146.
J Biol Chem. 2019 Feb 1;294(5):1671-1680. doi: 10.1074/jbc.TM118.004144.
In honor of the 100th birthday of Dr. Herbert Tabor, JBC's Editor-in-Chief for 40 years, I will review here JBC's extensive coverage of the field of cytochrome P450 (P450) research. Research on the reactions catalyzed by these enzymes was published in JBC before it was even realized that they were P450s, they have a "pigment" with an absorption maximum at 450 nm. After the P450 pigment discovery, reported in JBC in 1962, the journal proceeded to publish the methods for measuring P450 activities and many seminal findings. Since then, the P450 field has grown extensively, with significant progress in characterizing these enzymes, including structural features, catalytic mechanisms, regulation, and many other aspects of P450 biochemistry. JBC has been the most influential journal in the P450 field. As with many other research areas, Dr. Tabor deserves a great deal of the credit for significantly advancing this burgeoning and important topic of research.
为了纪念 Herbert Tabor 博士诞辰 100 周年，他曾担任 JBC 的主编长达 40 年，我将在这里回顾 JBC 对细胞色素 P450（P450）研究领域的广泛报道。这些酶催化的反应的研究在人们甚至还没有意识到它们是 P450 之前就在 JBC 上发表了，因为它们有一个在 450nm 处有最大吸收峰的“色素”。在 1962 年 JBC 报道了 P450 色素的发现之后，该杂志继续发表了测量 P450 活性的方法和许多重要发现。从那时起，P450 领域得到了广泛的发展，在表征这些酶方面取得了重大进展，包括结构特征、催化机制、调控以及 P450 生物化学的许多其他方面。JBC 一直是 P450 领域最具影响力的期刊。与许多其他研究领域一样，Tabor 博士在显著推进这一日益兴起和重要的研究课题方面功不可没。
