Phenotypic discrepancies in acetyl-CoA carboxylase 2-deficient mice.
作者信息
Hoehn Kyle L, Turner Nigel, Cooney George J, James David E
出版信息
J Biol Chem. 2012 May 4;287(19):15801; author reply 15802. doi: 10.1074/jbc.O112.356915.
Abstract
摘要
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本文引用的文献
1
Acetyl-CoA carboxylase 2-/- mutant mice are protected against fatty liver under high-fat, high-carbohydrate dietary and de novo lipogenic conditions.乙酰辅酶 A 羧化酶 2 基因敲除小鼠在高脂肪、高碳水化合物饮食和从头合成脂肪条件下可防止脂肪肝形成。
J Biol Chem. 2012 Apr 6;287(15):12578-88. doi: 10.1074/jbc.M111.309559. Epub 2012 Feb 23.
2
Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity.急性或慢性上调线粒体脂肪酸氧化对全身能量消耗或肥胖没有净效应。
Cell Metab. 2010 Jan;11(1):70-6. doi: 10.1016/j.cmet.2009.11.008.
3
Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity.乙酰辅酶A羧化酶2基因敲除小鼠体内持续的脂肪氧化增加了总能量消耗，减少了脂肪量，并改善了胰岛素敏感性。
Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16480-5. doi: 10.1073/pnas.0706794104. Epub 2007 Oct 8.
4
Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets.乙酰辅酶A羧化酶2突变小鼠可抵御高脂/高碳水化合物饮食诱导的肥胖和糖尿病。
Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10207-12. doi: 10.1073/pnas.1733877100. Epub 2003 Aug 14.
5
Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2.缺乏乙酰辅酶A羧化酶2的小鼠中脂肪酸持续氧化及脂肪储存减少
Science. 2001 Mar 30;291(5513):2613-6. doi: 10.1126/science.1056843.
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