Krishna M Vamshi, Prabhash Kumar, Noronha Vanita, Menon Santosh, Dua Sumeet G, Rangarajan V, Tangaonkar H B
Department of Medical Oncology, Tata Memorial Hospital, Parel, Mumbai, India.
Indian J Med Paediatr Oncol. 2011 Oct;32(4):233-7. doi: 10.4103/0971-5851.95149.
We present a patient with metastatic leiomyosarcoma of the prostate who achieved complete response with chemotherapy. A 70 years old male patient presented with urinary tract symptoms and a prostatic mass. After having been treated as carcinoma prostate, he presented with progressive pelvic mass, lung and bone metastases to our hospital. Repeat biopsy was suggestive of prostatic leiomyosarcoma. He was treated with chemotherapy with the ifosfamide-epirubicin regimen and achieved complete remission on positron emission tomography/computerized tomography after three cycles. He was given a total of six cycles of chemotherapy and continues to be disease-free after 8 months. Although adenocarcinomas are the commonest prostatic malignancies in the elderly, a careful evaluation is essential to rule out alternative diagnoses. Our case report illustrates the potential role of combination chemotherapy in the management of advanced leiomyosarcoma of the prostate. The literature on this entity is reviewed.
我们报告一例前列腺转移性平滑肌肉瘤患者，其通过化疗实现了完全缓解。一名70岁男性患者出现尿路症状和前列腺肿块。在被当作前列腺癌治疗后，他出现进行性盆腔肿块、肺和骨转移，随后到我院就诊。重复活检提示为前列腺平滑肌肉瘤。他接受了异环磷酰胺 - 表柔比星方案化疗，三个周期后正电子发射断层扫描/计算机断层扫描显示完全缓解。他总共接受了六个周期的化疗，8个月后仍无疾病进展。虽然腺癌是老年人最常见的前列腺恶性肿瘤，但仔细评估以排除其他诊断至关重要。我们的病例报告说明了联合化疗在晚期前列腺平滑肌肉瘤治疗中的潜在作用。本文对该疾病的相关文献进行了综述。
