Votiakov V I, Erokhina I R, Arkatov Iu M, Protas I I
Vopr Virusol. 1990 Jul-Aug;35(4):329-33.
The pattern of destructive alterations of neurons and their processes at different spinal cord levels in guinea pigs with experimental amyotrophic leukospongiosis (AL) was studied by light and electron microscopy. The destruction of a portion of neurons was found to be of retrograde degeneration type. Electron microscopy of spinal conduction pathways showed that degenerative alterations occurred not only in the neuronal soma or processes but also in synaptic structures. The results indicate primary involvement of nerve cell processes, particularly axons, in experimental AL. It is suggested that AL pathogenesis is pathomorphologically based on the uptake of the agent by axonal terminals.
通过光学显微镜和电子显微镜研究了实验性肌萎缩性白质海绵状脑病（AL）豚鼠不同脊髓节段神经元及其突起的破坏性改变模式。发现部分神经元的破坏属于逆行性变性类型。脊髓传导通路的电子显微镜检查显示，变性改变不仅发生在神经元胞体或突起中，也发生在突触结构中。结果表明神经细胞突起，尤其是轴突，在实验性AL中首先受累。提示AL的发病机制在病理形态学上基于轴突终末对病原体的摄取。
