Poleshchuk N N, Kvacheva Z B, Il'kevich Iu G, Kolomiets N D
Vopr Virusol. 1990 Sep-Oct;35(5):401-5.
The amyotrophic leukospongiosis (AL) agent which is considered to be an unconventional virus was shown to replicate and amplify in non-neuronal monolayer brain cell cultures. The AL agent persistence was accompanied by complicated morphofunctional changes in astrocytes, some of them developing a specific cytodystrophic process. Phagocytosis in the infected astrocytes came to its end. The dose-dependent effect and selective sensitivity of these cells to the cytodestructive activity of AL was demonstrated. Astrocytes are regarded to be target cells serving as a reservoir for agent amplification.
被认为是一种非常规病毒的肌萎缩性白质海绵状脑病（AL）病原体，已被证明能在非神经元单层脑细胞培养物中复制和扩增。AL病原体的持续存在伴随着星形胶质细胞复杂的形态功能变化，其中一些星形胶质细胞发生了特定的细胞营养不良过程。感染的星形胶质细胞中的吞噬作用终止。这些细胞对AL细胞破坏活性的剂量依赖性效应和选择性敏感性得到了证实。星形胶质细胞被认为是病原体扩增的储存库的靶细胞。
