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高功能自闭症谱系障碍(ASD)中的早期视觉处理异常

Early-stage visual processing abnormalities in high-functioning autism spectrum disorder (ASD).

作者信息

Baruth Joshua M, Casanova Manuel F, Sears Lonnie, Sokhadze Estate

机构信息

Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY 40202.

出版信息

Transl Neurosci. 2010 Jun;1(2):177-187. doi: 10.2478/v10134-010-0024-9.

Abstract

It has been reported that individuals with autism spectrum disorder (ASD) have abnormal responses to the sensory environment. For these individuals sensory overload can impair functioning, raise physiological stress, and adversely affect social interaction. Early-stage (i.e. within 200ms of stimulus onset) auditory processing abnormalities have been widely examined in ASD using event-related potentials (ERP), while ERP studies investigating early-stage visual processing in ASD are less frequent. We wanted to test the hypothesis of early-stage visual processing abnormalities in ASD by investigating ERPs elicited in a visual oddball task using illusory figures. Our results indicate that individuals with ASD have abnormally large cortical responses to task irrelevant stimuli over both parieto-occipital and frontal regions-of-interest (ROI) during early stages of visual processing compared to the control group. Furthermore, ASD patients showed signs of an overall disruption in stimulus discrimination, and had a significantly higher rate of motor response errors.

摘要

据报道,患有自闭症谱系障碍(ASD)的个体对感觉环境有异常反应。对于这些个体而言,感觉过载会损害其功能、增加生理压力并对社交互动产生不利影响。使用事件相关电位(ERP)在ASD患者中对早期阶段(即刺激开始后200毫秒内)的听觉处理异常进行了广泛研究,而在ASD患者中研究早期视觉处理的ERP研究则较少。我们想通过研究使用虚幻图形的视觉Oddball任务中诱发的ERP来检验ASD患者早期视觉处理异常的假设。我们的结果表明,与对照组相比,在视觉处理的早期阶段,ASD患者在顶枕和额叶感兴趣区域(ROI)对与任务无关的刺激有异常大的皮层反应。此外,ASD患者表现出刺激辨别整体中断的迹象,并且运动反应错误率明显更高。

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