比较电感耦合等离子体质谱法测量学龄前儿童发热性和无热惊厥时血清锌水平。
Comparison of serum zinc levels measured by inductively coupled plasma mass spectrometry in preschool children with febrile and afebrile seizures.
机构信息
Department of Pediatrics, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.
出版信息
Ann Lab Med. 2012 May;32(3):190-3. doi: 10.3343/alm.2012.32.3.190. Epub 2012 Apr 18.
BACKGROUND
Changes in levels of trace elements have been proposed to underlie febrile seizures. Particularly, low zinc levels have been proposed as related factor of febrile seizure. In this study, we investigated whether mean serum zinc levels differed between children with febrile seizure and afebrile seizure.
METHODS
Using inductively coupled plasma mass spectrometry, serum zinc levels were measured in 288 children who had been diagnosed with febrile seizures (N=248) and afebrile seizures (N=40). Mean serum zinc levels were compared between the 2 groups.
RESULTS
Mean serum zinc level was 60.5±12.7 µg/dL in the febrile seizure group and 68.9 ±14.5 µg/dL in the afebrile seizure group. A significant difference in serum zinc levels was observed between the febrile and afebrile seizure groups (P<0.001).
CONCLUSIONS
Zinc levels in children with febrile seizure were significantly lower than those in children with afebrile seizure.
背景
微量元素水平的变化被认为是热性惊厥的基础。特别是，低锌水平被认为是热性惊厥的相关因素。在这项研究中，我们调查了热性惊厥和无热惊厥患儿的血清锌水平是否存在差异。
方法
使用电感耦合等离子体质谱法，测量了 288 名被诊断为热性惊厥（N=248）和无热惊厥（N=40）的儿童的血清锌水平。比较了两组之间的平均血清锌水平。
结果
热性惊厥组的平均血清锌水平为 60.5±12.7 µg/dL，无热惊厥组为 68.9 ±14.5 µg/dL。热性惊厥组和无热惊厥组之间的血清锌水平存在显著差异（P<0.001）。
结论
热性惊厥患儿的锌水平明显低于无热惊厥患儿。
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