Arul Janani, Kommu Peter Prasanth Kumar, Kasinathan Ananthanarayanan, Ray Lopamudhra, Krishnan Lalitha
Department of Pediatrics, Pondicherry Institute of Medical Sciences, Puducherry, India.
Department of Biochemistry, Pondicherry Institute of Medical Sciences, Puducherry, India.
J Neurosci Rural Pract. 2020 Oct;11(4):597-600. doi: 10.1055/s-0040-1715992. Epub 2020 Sep 8.
To estimate the serum zinc levels in children under the age of 5 years with febrile seizures and febrile children without seizures In this cross-sectional study from 2017 to 2018, 40 children with febrile seizures (simple and complex) were taken as cases. Forty age- and sex-matched febrile children without convulsions were recruited as controls. Serum zinc estimates were analyzed using a spectrophotometer (Biolis 50i-Autoanalyzer). The demographic variables and serum zinc estimates were analyzed using the Mann-Whitney test. The odds ratio was used to calculate the association of zinc deficiency in febrile seizures; 5% level of significance was considered. The mean serum concentrations of zinc in the cases and controls were 83.8 ± 33.1 μg/dL and 116.3 ± 30.3 μg/dL, respectively ( = 0.002). Hypozincemia defined by "a serum zinc level of less than 63 μg/dL" was found in 12 (30%) cases and 2(5%) controls with an odds ratio of 8:1. Children with febrile seizures had significantly reduced concentrations of zinc in the serum.
评估5岁以下热性惊厥儿童和无热性惊厥发热儿童的血清锌水平 在这项2017年至2018年的横断面研究中，40例热性惊厥（简单型和复杂型）儿童作为病例组。招募40例年龄和性别匹配的无惊厥发热儿童作为对照组。使用分光光度计（Biolis 50i自动分析仪）分析血清锌含量。 使用曼-惠特尼检验分析人口统计学变量和血清锌含量。比值比用于计算热性惊厥中锌缺乏的关联；显著性水平设定为5%。 病例组和对照组的血清锌平均浓度分别为83.8±33.1μg/dL和116.3±30.3μg/dL（P=0.002）。血清锌水平低于63μg/dL定义的低锌血症在12例（30%）病例组和2例（5%）对照组中出现，比值比为8:1。 热性惊厥儿童血清锌浓度显著降低。
