热性惊厥患儿血清微量元素的病例对照研究
SerumTrace Elements in Febrile Seizure: A Case-Control Study.
作者信息
Namakin Kokab, Zardast Mahmoud, Sharifzadeh Golamreza, Bidar Toktam, Zargarian Samaneh
机构信息
Birjand atherosclerosis and coronary artery research center, Birjand University of Medical Sciences (BUMS), Birjand, Iran.
Birjand atherosclerosis and coronary artery research center, Department of pathology, Birjand University of Medical Sciences (BUMS), Birjand, Iran.
出版信息
Iran J Child Neurol. 2016 Summer;10(3):57-60.
OBJECTIVE
Febrile seizure (FS) is one of the most common neurological problems during childhood.Pathogenesis of febrile convulsion is unknown. This study investigated some trace elements among children admitted with FS compared with thoseof febrile without seizure attacks.
MATERIALS & METHODS: This case-control study was conducted on48 children (6 months to 5 yrold) diagnosed with febrile seizure as the cases and 48 age-matched febrile children as the control group. Serum levels of magnesium, calcium, sodium, potassium, and serum zinc were measured. Statistical analysis was performed with SPSS (version 15) using Student t-test.
RESULTS
There were no significant differences between the cases and controls in terms of gender or age. The means of serum level of zinc, sodium, calcium and magnesium in the case group was lower than those of the control group. There was no significant difference onserum potassium mean level between the case and control groups.
CONCLUSION
Deficiency of trace elements was correlated significantly with febrile convulsion, while further investigations on trace elements are required.
目的
热性惊厥（FS）是儿童期最常见的神经系统问题之一。热性惊厥的发病机制尚不清楚。本研究调查了热性惊厥患儿与无惊厥发作的发热患儿的一些微量元素情况。
材料与方法
本病例对照研究选取48例诊断为热性惊厥的儿童（6个月至5岁）作为病例组，48例年龄匹配的发热儿童作为对照组。检测血清镁、钙、钠、钾水平及血清锌水平。使用SPSS（15版）软件进行统计学分析，采用学生t检验。
结果
病例组和对照组在性别或年龄方面无显著差异。病例组血清锌、钠、钙和镁水平的均值低于对照组。病例组和对照组血清钾平均水平无显著差异。
结论
微量元素缺乏与热性惊厥显著相关，仍需对微量元素进行进一步研究。
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