Wibowo Noroyono, Purwosunu Yuditiya, Sekizawa Akihiko, Farina Antonio, Idriansyah Liana, Fitriana Ika
Department of Obstetrics and Gynecology, University of Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia.
J Obstet Gynaecol Res. 2012 Sep;38(9):1152-61. doi: 10.1111/j.1447-0756.2012.01855.x. Epub 2012 May 8.
The aim of this study was to investigate the benefit of antioxidant supplementation in a cohort of women with low antioxidant status and determine the changes in cell-free mRNA.
This study was a randomized, placebo-controlled trial of 8-12 weeks' pregnant women who had low antioxidant status treated with either antioxidants or control diets daily until 2 weeks' postpartum. The primary end-point was the risk of pre-eclampsia and the secondary end-point was the changes of angiogenic and anti-oxidant mRNA markers related to the outcome (ClinicalTrial.gov, number NCT01232205).
There were 110 women enrolled in the study, randomly assigned to the supplementation (n = 52) and control group (n = 58). The overall rate of pre-eclampsia was 8.7% (nine subjects). There were significant differences (P = 0.034) between the supplementation and control group in the incidence of pre-eclampsia (2.0% [one case] and 14.5% [eight cases], respectively) and mRNA level of superoxide-dismutase, heme oxygenase-1, vascular endothelial growth factor receptor-1, endoglin and placental growth factor after supplementation.
Supplementation of women with low antioxidant status with micronutrients containing antioxidants during early gestation might reduce the risk of pre-eclampsia.
本研究旨在调查抗氧化剂补充剂对一组抗氧化状态较低的女性的益处，并确定游离mRNA的变化。
本研究是一项随机、安慰剂对照试验，对象为抗氧化状态较低的8至12周孕妇，她们每天接受抗氧化剂或对照饮食治疗，直至产后2周。主要终点是先兆子痫的风险，次要终点是与该结果相关的血管生成和抗氧化mRNA标志物的变化（ClinicalTrial.gov，编号NCT01232205）。
共有110名女性参与研究，随机分为补充剂组（n = 52）和对照组（n = 58）。先兆子痫的总体发生率为8.7%（9名受试者）。补充剂组和对照组在先兆子痫的发生率（分别为2.0% [1例]和14.5% [8例]）以及补充后超氧化物歧化酶、血红素加氧酶-1、血管内皮生长因子受体-1、内皮糖蛋白和胎盘生长因子的mRNA水平方面存在显著差异（P = 0.034）。
在妊娠早期，为抗氧化状态较低的女性补充含抗氧化剂的微量营养素可能会降低先兆子痫的风险。
