Department of Chemistry, Kangwon National University, Chuncheon 200-701, Republic of Korea.
J Org Chem. 2012 May 18;77(10):4821-5. doi: 10.1021/jo300236u. Epub 2012 May 9.
Indium tri(isopropoxide)-catalyzed Meerwein-Ponndorf-Verley reduction of aliphatic and aromatic aldehydes in 2-propanol gave selectively the corresponding primary alcohols in good to excellent yields at room temperature. A wide range of functional groups including alkene, ether, ketone, ester, nitrile, and nitro were tolerated under the optimum reaction conditions. Chemoselective reductions were also achieved not only between aromatic aldehyde, aromatic ketone, and epoxide but also between aliphatic aldehyde and alkene.
三异丙氧基铟-催化的 Meerwein-Ponndorf-Verley 还原反应，可在室温下以 2-丙醇为溶剂，对脂肪族和芳香族醛进行选择性还原，得到相应的伯醇，产率高、效果好。在最佳反应条件下，包括烯烃、醚、酮、酯、腈和硝基在内的各种官能团都能被容忍。不仅在芳香醛、芳香酮和环氧化物之间，而且在脂肪醛和烯烃之间，也能实现化学选择性还原。
