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高功率二极管激光与电灼术治疗人乳头瘤病毒病变的比较

High-power diode laser versus electrocautery surgery on human papillomavirus lesion treatment.

作者信息

Baeder Fernando Martins, Santos Maria Teresa Botti R, Pelino Jose Eduardo Pelizon, Duarte Danilo Antonio, Genovese Walter Joao

机构信息

Rehabilitation Center Lar Escola São Francisco, Centro de Reabilitação, São Paulo, Brazil.

出版信息

J Craniofac Surg. 2012 May;23(3):702-5. doi: 10.1097/SCS.0b013e31824dba38.

Abstract

The use of high-power lasers has facilitated and improved human papillomavirus (HPV) treatment protocols and has also become very popular in recent years. This application has been more frequently used in hospitals, especially in gynecology. The present study aimed to evaluate the effects of high-power diode laser to remove oral lesions caused by HPV and the consequent effects on virus load following the wound tissue healing process compared with one of the most conventional surgical techniques involving electrocautery. Surgeries were performed on 5 patients who had 2 distinct lesions caused by HPV. All patients were submitted to both electrocautery and high-power diode laser. Following a 20-day period, when the area was healed, sample material was collected through curettage for virus load quantitative analysis.Observation verified the presence of virus in all the samples; however, surgeries performed with the laser also revealed a significant reduction in virus load per cell compared with those performed with electrocautery. The ease when handling the diode laser, because of the flexibility of its fibers and precision of its energy delivery system, provides high-accuracy surgery, which facilitates the treatment of large and/or multifocal lesions. The use of high-power diode laser is more effective in treatment protocols of lesions caused by HPV.

摘要

高功率激光的使用推动并改进了人乳头瘤病毒(HPV)的治疗方案,近年来也变得非常流行。这种应用在医院中使用得越来越频繁,尤其是在妇科。本研究旨在评估高功率二极管激光去除HPV引起的口腔病变的效果,以及与最传统的电灼手术技术之一相比,伤口组织愈合过程后对病毒载量的后续影响。对5名患有2种由HPV引起的不同病变的患者进行了手术。所有患者均接受了电灼和高功率二极管激光治疗。在20天的愈合期后,当伤口愈合时,通过刮除术收集样本材料进行病毒载量定量分析。观察发现所有样本中均存在病毒;然而,与电灼手术相比,激光手术的每个细胞病毒载量也显著降低。由于二极管激光光纤的灵活性及其能量传输系统的精确性,其操作简便,可提供高精度手术,便于治疗大的和/或多灶性病变。高功率二极管激光在HPV引起的病变治疗方案中更有效。

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