Eskenasy A
Morphol Embryol (Bucur). 1979 Apr-Jun;25(2):139-51.
A hundred and twenty-five cases of bronchiolo-alveolar cell carcinomas observed between 1954 and 1978 were histopathologically analysed, some of them also histoenzymatically. The material comprised 93 lung resections (56 lobectomies and 37 pulmonectomies). 11 intraoperatory biopsies in inoperable cases, and 21 autopsies. The early discovery and treatment of the overwhelming majority of cases allow the observation of uncomplicated lesions, the bronchiolar involvement followed by alveolar invasion due to sliding of neoplastic cells on denuded alveolar walls often thickened by cell and fibril accumulation, the papillary formations, as well as the histoenzymatic behaviour. The latter evidenced the strong relations of neoplastic cells with the normal bronchiolar cells (glucose-6-phosphate dehydrogenase. Mg-dependent ATP-ase, oxidoreductases). Some peculiarities also point to the existence of a possible second parallel origin of neoplastic cells at the level of large alveolocytes during the morphogenesis of this multicentric lung carcinoma.
对1954年至1978年间观察到的125例细支气管肺泡细胞癌进行了组织病理学分析，其中部分病例还进行了组织酶学分析。材料包括93例肺切除术（56例肺叶切除术和37例全肺切除术）、11例无法手术病例的术中活检以及21例尸检。绝大多数病例的早期发现和治疗使得能够观察到未并发的病变、细支气管受累情况，继而是由于肿瘤细胞在常因细胞和纤维积聚而增厚的裸露肺泡壁上滑动导致的肺泡侵犯、乳头状结构以及组织酶学表现。后者证明了肿瘤细胞与正常细支气管细胞（葡萄糖-6-磷酸脱氢酶、镁依赖性ATP酶、氧化还原酶）之间的密切关系。一些特点还表明，在这种多中心肺癌的形态发生过程中，肿瘤细胞可能在大肺泡细胞水平存在第二种平行起源。
