Barz H, Barz D, Klemm P
Arch Geschwulstforsch. 1982;52(7):551-60.
The distribution of metastatic tumors of 935 lung cancers with blood borne metastases has been analysed. The frequency of affected organs decreased in the following sequence: liver, bone, adrenal, brain, lung, kidney, thyroid gland, pancreas, spleen and heart. In cases with only one metastatic affected organ the frequency of brain and lung metastases is greater than the frequency of liver, bone and adrenal metastases. Especially in cases with two different affected organs the pair combination of liver and bone metastases as well as of brain and adrenal metastases is evident, however, combined brain and bone metastases and brain and liver metastases rarely occur. The distinct pattern of metastatic distribution in the body supports the evidence of the "soil" hypothesis. Seldom affected organs rarely shows a strong metastatic involvement and go hand in hand with many other affected organs. In autopsies the duration of cancer disease is much longer in cases without metastasis or small metastatic involvement than in cases with many affected organs. Therefore, the generalization of metastatic spread mainly depends on the malignancy of tumors and to a less extent on the duration of cancer disease.
对935例发生血行转移的肺癌转移瘤分布情况进行了分析。受累器官的发生频率按以下顺序递减：肝脏、骨骼、肾上腺、脑、肺、肾、甲状腺、胰腺、脾脏和心脏。在仅有一个转移受累器官的病例中，脑转移和肺转移的频率高于肝转移、骨转移和肾上腺转移的频率。特别是在有两个不同受累器官的病例中，肝转移与骨转移以及脑转移与肾上腺转移的配对组合很明显，然而，脑转移合并骨转移以及脑转移合并肝转移很少发生。体内转移分布的独特模式支持了“土壤”假说的证据。很少受累的器官很少出现强烈的转移累及，且与许多其他受累器官同时出现。在尸检中，无转移或转移累及较小的病例中癌症病程比有许多受累器官的病例长得多。因此，转移扩散的普遍性主要取决于肿瘤的恶性程度，而在较小程度上取决于癌症病程。
