Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Institute of Medical Biology, Chinese Academy of Medicine Science, Kunming 650118, China.
Sci China Life Sci. 2012 Apr;55(4):336-42. doi: 10.1007/s11427-012-4313-z. Epub 2012 May 9.
Coxsackie A virus is one of the major pathogens associated with hand, foot and mouth disease (HFMD). The etiological characteristics of Coxsackie A virus type 16 (CA16) are thought to correlate with the pathological process of its infection. Two CA16 strains that were isolated from a severe HFMD patient presented with different plaque forms. This observation, along with biological analysis, indicated that the differences in the strains' biological characteristics, such as proliferation kinetics and immunogenicity, correlate with differences in their pathogenicity toward neonatal mice. Furthermore, these differences are thought to be associated with the sequence of the 5' non-coding region of the viral genome and the VP1 structural region sequence. The results suggest that the biological and genetic characteristics of the CA16 viral strains are relevant to their pathogenicity.
柯萨奇 A 病毒是引起手足口病（HFMD）的主要病原体之一。柯萨奇 A 病毒 16 型（CA16）的病因特征被认为与感染的病理过程相关。从一名重症 HFMD 患者中分离出的两株 CA16 呈现出不同的噬斑形态。这一观察结果以及生物学分析表明，这些株的生物学特性差异，如增殖动力学和免疫原性，与它们对新生小鼠的致病性差异相关。此外，这些差异被认为与病毒基因组的 5'非编码区和 VP1 结构区序列有关。结果表明，CA16 病毒株的生物学和遗传特征与其致病性相关。
