1981年至2007年间从日本富山县手足口病患者中分离出的柯萨奇病毒A16和肠道病毒71的基因变化。
Genetic changes of coxsackievirus A16 and enterovirus 71 isolated from hand, foot, and mouth disease patients in Toyama, Japan between 1981 and 2007.
作者信息
Iwai Masae, Masaki Akio, Hasegawa Sumiyo, Obara Mayumi, Horimoto Eiji, Nakamura Kazuya, Tanaka Yuichi, Endo Kyoko, Tanaka Keiko, Ueda Junko, Shiraki Kimiyasu, Kurata Takeshi, Takizawa Takenori
机构信息
Department of Virology, Toyama Institute of Health, Imizu-shi, Toyama, Japan.
出版信息
Jpn J Infect Dis. 2009 Jul;62(4):254-9.
We characterized the genetic diversity of the complete VP1 region of coxsackievirus A16 (CA16) and enterovirus 71 (EV71) isolated from patients with hand, foot, and mouth disease in Toyama from 1981 to 2007 to evaluate the relationship between epidemics and genetic changes. The predominant genogroups of CA16 changed from B to C in 1995-1998, and genogroup C further changed from subgenogroup C1 to C2 around 2002, and to C3 in 2005-2007. The subgenogroups of the EV71 isolates were classified into B1, B4, C1, and C3 in 1983-1994, and into C4 in 1997-2006. However, changes of the amino acid sequences of the VP1 regions of CA16 were restored, and those of the EV71 isolates were not observed among the same subgenogroups during this survey period, indicating that the prevalence that occurred at intervals of several years seemed to depend on an accumulating number of immunologically naive children, not viral antigenic changes.
我们对1981年至2007年从富山手足口病患者中分离出的柯萨奇病毒A16（CA16）和肠道病毒71型（EV71）完整VP1区域的遗传多样性进行了表征，以评估疫情与基因变化之间的关系。CA16的主要基因型在1995 - 1998年从B型变为C型，C基因型在2002年左右进一步从C1亚基因型变为C2亚基因型，并在2005 - 2007年变为C3亚基因型。1983 - 1994年，EV71分离株的亚基因型分为B1、B4、C1和C3型，1997 - 2006年分为C4型。然而，在本调查期间，同一亚基因型中未观察到CA16的VP1区域氨基酸序列的变化得到恢复，而EV71分离株的氨基酸序列变化则未出现，这表明每隔几年发生的流行似乎取决于免疫原初儿童数量的积累，而非病毒抗原性的变化。
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