单链诱导RecA蛋白解开双链DNA以进行同源配对。
Single strands induce recA protein to unwind duplex DNA for homologous pairing.
作者信息
Cunningham R P, Shibata T, DasGupta C, Radding C M
出版信息
Nature. 1979 Sep 20;281(5728):191-5. doi: 10.1038/281191a0.
DOI:10.1038/281191a0
PMID:225671
Abstract
Single-stranded DNA, whether homologous or not, stimulates purified Escherichia coli recA protein to unwind duplex DNA. This helps to explain how recA promotes a search for homology in genetic recombination. As oligodeoxynucleotide also stimulate unwinding, a common mechanism may relate the function of recA protein in recombination to other functions (SOS) induced by oligonucleotides.
摘要
单链DNA，无论是否同源，都能刺激纯化的大肠杆菌recA蛋白解开双链DNA。这有助于解释recA如何在基因重组中促进同源性搜索。由于寡脱氧核苷酸也能刺激解旋，一种共同的机制可能将recA蛋白在重组中的功能与寡核苷酸诱导的其他功能（SOS）联系起来。
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