一名患有卵黄囊瘤的女性对静脉注射依托泊苷发生I型超敏反应的管理：病例报告

Management of a Type I Hypersensitivity Reaction to IV Etoposide in a Woman with a Yolk Sac Tumor: A Case Report.

作者信息

Starks David, Prinz Deborah, Armstrong Amy, Means Lindsay, Waggoner Steven, Debernardo Robert

机构信息

MacDonald Women's Hospital, University Hospitals Case Medical Center, Cleveland, OH 44106, USA.

出版信息

Case Rep Obstet Gynecol. 2011;2011:837160. doi: 10.1155/2011/837160. Epub 2011 Sep 8.

DOI:10.1155/2011/837160

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3335558/

Abstract

Type I hypersensitivity reactions to intravenous administration of etoposide are extremely rare. Etoposide is an essential component of several chemotherapy regimens used in gynecologic oncology, and discontinuation of this drug during a course of treatment should only be due to severe patient intolerance. We report the successful use of intravenous etoposide phosphate as a substitute drug in a patient with a yolk sac tumor who manifested a Type I hypersensitivity to intravenous etoposide. The patient ultimately completed all 4 cycles of bleomycin, etoposide, cisplatin (BEP) using etoposide phosphate as a substitute drug.

摘要

静脉注射依托泊苷引起的I型超敏反应极为罕见。依托泊苷是妇科肿瘤学中几种化疗方案的重要组成部分，在一个疗程中停用该药物仅应是由于患者严重不耐受。我们报告了一名卵黄囊瘤患者成功使用静脉注射磷酸依托泊苷替代对静脉注射依托泊苷表现出I型超敏反应的依托泊苷。该患者最终使用磷酸依托泊苷替代药物完成了所有4个周期的博来霉素、依托泊苷、顺铂（BEP）化疗。

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本文引用的文献

1

Successful treatment with etoposide phosphate in patients with previous etoposide hypersensitivity.磷酸依托泊苷成功治疗既往有依托泊苷过敏反应的患者。

J Oncol Pharm Pract. 2008 Mar;14(1):51-5. doi: 10.1177/1078155207085355.

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